TABLE 1.
Replication of WNV-NY in human cell lines
| Cell line | Tissue/morphology | CPE | WNV protein expressiona | Release of viral particlesb |
|---|---|---|---|---|
| Vero | Monkey kidney/epithelial | Yes | Yes | Yes |
| HeLa | Human cervix/epithelial | No | Yes | ND |
| 293 | Human kidney/epithelial | Yes | Yes | Yes |
| Huh7 | Human liver/hepatocyte | Yes | Yes | Yes |
| Tel12 | Human foreskin/fibroblast | Yes | NDc | ND |
| HFF | Human primary foreskin/ fibroblast | Yes | Yes | ND |
| GRE | Human brain/glial | Yes | Yes | Yes |
| U-2 OS | Human bone/epithelial | Yes | Yes | Yes |
| MEF | Mouse embryo/fibroblast | Yes | Yes | Yes |
a
Viral protein production was assessed by either immunofluorescence assay or Western blot analysis.
b
The production of infectious particles was confirmed by plaque assay on Vero cells.
c
ND, not determined.