Table 1.
The differences of the single nucleotide polymorphisms in the ITGA5 , ITGB1 , IL10 , COX-2 , RUNX3 , and TFF2 genes between 195 children of gastric cancer patients and 143 duodenal ulcer patients
| Parameters N (%) | GCA children | DU patients | P * | P ** | OR (95% CI) |
|---|---|---|---|---|---|
| Age (yr) | 38.2 ± 10.6 | 49.2 ± 13.8 | 1×10-4 | ||
| Gender (F: M) | 99 (51): 96 (49) | 59 (41): 84 (59) | 0.050 | 0.096 | 1.5 (1.0 - 2.3) |
| H. pylori (+: -) | 88 (48): 97 (52) | 110 (79): 29 (21) | <1×10-4 | <1×10-4 | 0.2 (0.1 - 0.4) |
| ITGA5 | |||||
| ITGA5 -1160 | (N = 195) | (N = 139) | |||
| T-carrier: GG | 154 (79): 41 (21) | 90 (65): 49 (35) | 0.017 | 0.006 | 2.2 (1.2 - 4.0) |
| ITGA5 -240 | (N = 193) | (N = 138) | |||
| CC: CT | 190 (98): 3 (2) | 136 (99): 2 (1) | 0.751 | 1.000 | 0.3 (0.0 - 3.1) |
| ITGB1 | |||||
| ITGB1 -1949 | (N = 189) | (N = 136) | |||
| A-carrier: GG | 158 (84): 31 (16) | 101 (74): 35 (26) | 0.047 | 0.047 | 2.8 (1.4 - 5.3) |
| ITGB1 -1840 | (N = 189) | (N = 136) | |||
| CC: T-carrier | 100 (53): 89 (47) | 75 (55): 61 (45) | 0.872 | 0.735 | 0.9 (0.6 - 1.6) |
| ITGB1 -1575 | (N = 189) | (N = 136) | |||
| AA: G-carrier | 10 (5): 179 (95) | 15 (11): 121 (89) | 0.034 | 0.059 | 0.3 (0.1 - 0.8) |
| ITGB1 -685 | (N = 185) | (N = 126) | |||
| -/-: -/C | 26 (14): 159 (86) | 13 (10): 113 (90) | 0.633 | 0.386 | 1.5 (0.7 - 3.4) |
| IGB1 -1660 | (N = 192) | (N = 138) | |||
| TTTAA/TTTAA: others | 165 (86): 27 (14) | 117 (85): 21 (15) | 0.385 | 0.877 | 0.9 (0.5 - 1.7) |
| ITGB1 +31804 | (N = 189) | (N = 136) | |||
| C-carrier: TT | 180 (95): 9 (5) | 119 (88): 17 (13) | 0.003 | 0.013 | 4.7 (1.7 - 13.0) |
| ITGB1 +32492 | (N = 189) | (N = 136) | |||
| G-carrier: AA | 97 (51): 92 (49) | 57 (42): 79 (58) | 0.022 | 0.113 | 1.7 (1.0 - 2.9) |
| IL10 | |||||
| IL10 -1082 | (N = 190) | (N = 138) | |||
| AA: G-carrier | 172 (91): 18 (9) | 121 (88): 17 (12) | 0.216 | 0.839 | 1.7 (0.7 - 3.9) |
| IL10 -819 | (N = 193) | (N = 138) | |||
| TT: C-carrier | 101 (52): 92 (48) | 53 (38): 85 (62) | 0.022 | 0.014 | 2.3 (1.4 - 4.0) |
| IL10 -592 | (N = 193) | (N = 138) | |||
| AA: C-carrier | 101 (52): 92 (48) | 53 (38): 85 (62) | 0.022 | 0.014 | 2.3 (1.4 - 4.0) |
| COX-2 | |||||
| COX-2 -1195 | (N = 189) | (N = 129) | |||
| G-carrier: AA | 156 (83): 33 (17) | 92 (71): 37 (29) | 0.064 | 0.019 | 1.7 (0.9 - 3.2) |
| COX-2 +8473 | (N = 194) | (N = 138) | |||
| TT: C-carrier | 134 (69): 60 (31) | 84 (61): 54 (39) | 0.259 | 0.129 | 1.4 (0.9 - 2.3) |
| RUNX3 | |||||
| RUNX3 -18508 | (N = 186) | (N = 135) | |||
| C-carrier: GG | 130 (70): 56 (30) | 100 (74): 35 (26) | 0.586 | 0.449 | 0.7 (0.4 - 1.2) |
| RUNX3 -1714 | (N = 193) | (N = 137) | |||
| CC: A-carrier | 109 (56): 84 (44) | 68 (50): 69 (50) | 0.302 | 0.261 | 1.3 (0.7 - 2.1) |
| RUNX3 -1582 | (N = 189) | (N = 136) | |||
| T-carrier: CC | 84 (44): 105 (56) | 69 (51): 67 (49) | 0.338 | 0.307 | 0.9 (0.5 - 1.4) |
| RUNX3 -1166 | (N = 193) | (N = 137) | |||
| TT: C-carrier | 109 (56): 84 (44) | 68 (50): 69 (50) | 0.302 | 0.258 | 1.3 (0.7 - 2.1) |
| RUNX3 +492 | (N = 189) | (N = 136) | |||
| TT: A-carrier | 106 (56): 83 (44) | 67 (49): 69 (51) | 0.312 | 0.263 | 1.2 (0.7 - 2.1) |
| RUNX3 +73375 | (N = 189) | (N = 135) | |||
| CC: A-carrier | 45 (24): 144 (76) | 23 (17): 112 (83) | 0.122 | 0.167 | 1.5 (0.8 - 2.9) |
| TFF2 | |||||
| TFF2 -1373 | (N = 189) | (N = 136) | |||
| CC: T-carrier | 139 (74): 50 (26) | 97 (71): 39 (29) | 0.692 | 0.702 | 1.0 (0.6 - 1.8) |
| TFF2 -503 | (N = 189) | (N = 136) | |||
| AA: G-carrier | 139 (74): 50 (26) | 97 (71): 39 (29) | 0.692 | 0.706 | 1.0 (0.6 - 1.8) |
| TFF2 -308 | (N = 189) | (N = 136) | |||
| CC: A-carrier | 85 (45): 104 (55) | 53 (39): 83 (61) | 0.394 | 0.311 | 1.2 (0.7 - 2.1) |
| TFF2 +4649 | (N = 188) | (N = 136) | |||
| GG: A-carrier | 100 (53): 88 (47) | 64 (47): 72 (53) | 0.343 | 0.308 | 1.4 (0.8 - 2.4) |
GCA: gastric cancer. DU: duodenal ulcer. SNPs: single nucleotide polymorphisms. *P value by mixed effect model. **P value by permutation test.