Table 2.
The comparisons of the genomic difference in the combinations of ITGA5 -1160 T-carrier, ITGB1 -1949 A-carrier, ITGB1 +31804 C-carrier, IL10 -592 AA and COX-2 -1195 G-carrier between the children of gastric cancer patients and the duodenal ulcer controls
| Predisposing SNPs | Risk SNPs N (%) | GCA children | DU controls | P * | P ** | OR (95% CI) |
|---|---|---|---|---|---|---|
| ITGA5 -1160 | (N = 189) | (N = 134) | ||||
| T-carrier | 3R:2R:1R:0R | 126(67): 49(26): 12(6): 2(1) | 63(47): 48(36): 18(13): 5(4) | 0.002 | ||
| ITGB1 -1949 | ||||||
| A-carrier | 3R | 126 (67) | 63 (47) | 0.225 | 0.050 | 5 (0.9 - 26.5) |
| ITGB1 +31804 | 2R | 49 (26) | 48 (36) | 0.539 | 0.514 | 2.6 (0.5 - 13.8) |
| C-carrier | 1R | 12 (6) | 18 (23) | 0.575 | 0.756 | 1.7 (0.3 - 10.0) |
| 0R | 2 (21) | 5 (4) | 1 | |||
| COX-2 -1195 | (N = 188) | (N = 125) | ||||
| G-carrier | 2R: 1R: 0R | 80 (43): 93 (49): 15 (8) | 31 (25): 75 (60): 19 (15) | 0.013 | ||
| With or without | ||||||
| IL-10 -592 AA | 2R | 80 (43) | 31 (25) | 0.021 | 0.005 | 3.3 (1.5 - 7.2) |
| 1R | 93 (49) | 75 (60) | 0.457 | 0.344 | 1.6 (0.7 - 3.3) | |
| 0R | 15 (8) | 19 (15) | 1 | |||
| ITGA5-1160 | (N = 185) | (N = 124) | ||||
| T-carrier | 2R: 1R: 0R | 44 (24): 115 (62): 26 (14) | 10 (8): 67 (54): 47 (38) | <1×10-4 | ||
| ITGB1 -1949 | ||||||
| A-carrier | ||||||
| ITGB1 +31804 | 2R | 44 (24) | 10 (8) | <1×10-4 | <1×10-4 | 8.0 (3.4 - 18.4) |
| C-carrier | 1R | 115 (62) | 67 (54) | 2×10-4 | 3×10-4 | 3.1 (1.8 - 5.5) |
| With or without | 0R | 26 (14) | 47 (38) | 1 | ||
| COX-2 -1195 | ||||||
| G-carrier | ||||||
| IL10 -592 AA | ||||||
| (N = 193) | (N = 135) | |||||
| IL-10 -592 AA | 2R: 1R: 0R | 74 (38): 105 (54): 14 (7) | 33 (24): 73 (54): 29 (21) | 4×10-4 | ||
| With or without | ||||||
| ITGA5 -1160 | 2R | 74 (38) | 33 (24) | 1×10-4 | <1×10-4 | 4.6 (2.2 - 9.9) |
| T-carrier | 1R | 105 (54) | 73 (54) | 6×10-4 | 0.003 | 3.0 (1.5 - 6.0) |
| 0R | 14 (7) | 29 (21) | 1 |
GCA: gastric cancer. DU: duodenal ulcer. SNPs: single nucleotide polymorphisms. 3R: the presence of 3 predisposing SNPs with risk alleles. 2R: the presence of 2 predisposing SNPs with risky alleles.
1R: the presence of 1 predisposing SNP with risk allele. 0R: no any predisposing SNPs with risk alleles. *P value by mixed effect model; **P value by permutation test.