Table 5.
The risk of SPEM increases stepwise for ITGA5 -1160 T-carrier, ITGB1 -1949 A-carrier, ITGB1 +31804 C-carrier, COX-2 -1195 G-carrier, and IL10 -592 AA to combine with RUNX3 +492 as A-carrier & TFF2 -308 as CC in the children of gastric cancer patients
| Predisposing SNPs | Risk SNPs N (%) | SPEM (+) | SPEM (−) | P * | P ** | OR (95% CI) |
|---|---|---|---|---|---|---|
| ITGA5-1160/ITGB1- | 2R: 1R: 0R | 16 (53): 13 (43): 1 (3) | 1 (6): 10 (56): 7 (39) | <1×10−4 | ||
| 1949/ITGB1+31804/COX-2-1195/IL10-592 | 2R: 1R+ 0R | 16 (53): 14 (47) | 1 (6): 17 (94) | 5×104 | 0.001 | 19.4 (2.3-165.2) |
| as T*/A*/C*/G*/AA | ||||||
| 2R+ 1R: 0R | 29 (97): 1 (3) | 11 (61): 7 (39) | 5×10−4 | 0.003 | 18.5 (2.0-167.8) | |
| with or without | ||||||
| 2R | 16 (53) | 1 (6) | 1×10−4 | 1×10−4 | 112.0 (6.1-2057.3) | |
| RUNX3+492/TFF2-308 | 1R | 13 (43) | 10 (56) | 0.045 | 0.0518 | 9.1 (1.0-86.5) |
| as A*/CC | 0R | 1 (3) | 7 (39) | 1 |
SPEM: spasmolytic polypeptide-expressing metaplasia. SNPs: single nucleotide polymorphisms. 2R: the presence of 2 predisposing SNPs with risk alleles. 1R: the presence of 1 predisposing SNPs with risk allele. 0R: no any predisposing SNPs with risk alleles. *Indicated the carrier of the specific allele in SNPs. *P value by mixed effect model; **P value by permutation test.