Table 1.

Cystatins dissociation constants (KIs) for different proteases

Enzyme	Family	Enzyme concentration	Ki (nM)
			rBrBmcys2b	rBrBmcys2c	rJpIocys2a
Cathepsin B 1	Cysteine protease	0.500 μM	0.82 ± 0.35	n.i.	154.70 ± 106.71
Cathepsin C 1	Cysteine protease	0.160 μM	26.65 ± 6.75	0.45 ± 0.12	>1 μM
Cathepsin L 2	Cysteine protease	0.043 μM	2.48 ± 1.00	28.45 ± 2.34	4.39 ± 1.76
Cathepsin G 2	Serine protease	0.100 μM	n.i	n.i.	n.i.

n.i., not inhibited in the presence of 0.5 μM recombinant cystatin.

¹Bovine cathepsin.

²Human cathepsin.