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Binding to the surface of intact GAS and bactericidal activity of affinity-purified human Mrp4N (MrpII family) antibodies against different emm types expressing homologous (MrpII) or heterologous (MrpIII) Mrps (A) and the relationship between Mrp antibody binding to GAS and observed bactericidal activity (B). Pearson's correlation coefficient was used to determine the significance of the relationship between Mrp antibody binding and bactericidal activity: r = 0.86, P < 0.05, n = 6.
