TABLE 2.
Complementation results for cell fusion
| Mutation or truncation | Domain | Extent of cell fusion by UL20-null complementationa
|
|
|---|---|---|---|
| gK (syn1) | gB (syn3) | ||
| Mutations | |||
| CL5 | I | ++++ | ++++ |
| CL11 | I | ++++ | ++++ |
| CL16 | I | ++++ | ++++ |
| CL23 | I | ++++ | ++++ |
| CL30 | I | +++ | ++++ |
| CL34 | I | +++ | +++ |
| CL38 | I | + | + |
| CL41 | I | ++ | ++++ |
| CL46 | I | ++ | ++++ |
| CL49 | I | ++ | ++ |
| Y49A | I | ++ | ++ |
| S50A | I | ++++ | ++++ |
| R51A | I | ++++ | ++++ |
| CL121 | III | ++ | ++ |
| CL153 | IV | − | − |
| E153A | IV | +++ | ++++ |
| T154A | IV | ++++ | ++++ |
| S156A | IV | ++++ | ++++ |
| D158A | IV | ++++ | ++++ |
| CL173 | IV | +++ | ++++ |
| CL177 | IV | ++++ | ++++ |
| CL209 | V | +++ | ++++ |
| R209A | V | ++++ | ++++ |
| T212A | V | ++++ | ++++ |
| R213A | V | +++ | ++++ |
| Truncations | |||
| 66t | − | − | |
| 149t | − | − | |
| 181t | − | − | |
| 204t | − | − | |
| 211t | − | − | |
| 216t | + | +++ | |
a
−, completely absent; +, very low levels of cell-fusion; ++, moderate levels; +++, near wild-type levels; ++++, wild-type levels.