Table 2. Multivariate hazard ratios and 95% confidence intervals of stroke incidence and mortality according to area deprivation level among 90 843 men and women.

	Area Deprivation Index					Trend P-value	Log- likelihood	Random effects (SD)
	0 (Least deprived)	1	2	3	4 (Most deprived)
n	18 159	17 992	18 230	18 282	18 180
Death
Person-years	288 735	300 655	304 956	302 767	296 639
Number of cases	202	225	242	226	252
Model 0							−12 858	0.08 (0.03)
Model 1	1.00	1.17 (0.95, 1.43)	1.32 (1.06, 1.65)	1.36 (1.05, 1.75)	1.79 (1.34, 2.39)	0.004	−12 817	0.024 (0.021)
Model 2	1.00	1.00 (0.82, 1.22)	1.04 (0.84, 1.28)	0.99 (0.76, 1.27)	1.02 (0.76, 1.38)	0.76	−12 495	0.001 (0.019)
Model 3	1.00	1.00 (0.82, 1.22)	1.04 (0.84, 1.29)	0.99 (0.76, 1.28)	1.02 (0.76, 1.37)	0.75	−12 448	0.001 (0.019)
Model 4	1.00	1.00 (0.82, 1.22)	1.03 (0.83, 1.29)	0.99 (0.77, 1.28)	1.02 (0.76, 1.38)	0.75	−12 450	0.002 (0.019)
Incidence
Person-years	273 578	282 021	283 995	282 766	274 064
Number of cases	735	911	879	959	926
Model 0							−49 061	0.049 (0.010)
Model 1	1.00	1.20 (1.06, 1.35)	1.14 (1.00, 1.30)	1.24 (1.07, 1.44)	1.32 (1.12, 1.56)	0.01	−49 027	0.029 (0.009)
Model 2	1.00	1.16 (1.04, 1.29)	1.12 (1.00, 1.26)	1.18 (1.02, 1.35)	1.19 (1.01, 1.41)	0.13	−48 209	0.009 (0.006)
Model 3	1.00	1.13 (1.02, 1.26)	1.09 (0.97, 1.23)	1.14 (1.00, 1.31)	1.13 (0.96, 1.33)	0.14	−48 094	0.008 (0.006)
Model 4	1.00	1.06 (0.96, 1.18)	1.02 (0.91, 1.14)	1.06 (0.93, 1.22)	1.05 (0.90, 1.23)	0.13	−47 984	0.003 (0.005)

SD, standard deviation.

Model 0 = Null model.

Model 1 = Area Deprivation Index (ADI) and PHC district were in the model.

Model 2 = Model 1 + age, gender, occupation and population density.

Model 3 = Model 2 + Behavioral and psychosocial factors (smoking, ethanol intake, physical activity, perceived psychological stress, marital status).

Model 4 = Model 2 + CVD biological risk factors (overweight, medical history of hypertension/diabetes/hyperlipidemia).