Table 2.

Toxicities in phase 1 (n = 15)

	Level 1 (n = 3)				Level 2 (n = 6)				Level 3 (n = 6)
Grade	1	2	3	4	1	2	3	4	1	2	3	4
Anemia	2	1	0	0	2	1	0	0	1	1	0	0
Blood bilirubin increased	0	0	0	0	1	0	0	0	1	0	0	0
Creatinine increased	0	0	0	0	2	0	0	0	0	0	0	0
Hyperglycemia	1	1	0	0	2	0	1	0	1	0	0	0
Neutrophil count decreased	0	0	0	0	0	0	0	0	0	1	0	0
Platelet count decreased	0	0	0	0	1	0	0	0	1	0	0	0
White blood cell count decreased	0	0	0	0	0	0	0	0	3	0	0	0
Anorexia	1	0	0	0	2	0	0	0	2	1	1	0
Diarrhea	0	0	0	0	4	0	0	0	5	1	0	0
Dry mouth	0	0	0	0	1	0	0	0	1	0	0	0
Dry skin	0	0	0	0	2	0	0	0	2	0	0	0
Fatigue	1	0	0	0	3	0	0	0	1	0	0	0
Oral mucositis	0	0	0	0	2	0	0	0	4	1	0	0
Nausea	1	0	0	0	1	0	0	0	3	0	1	0
Papulopustular rash	0	0	0	0	0	0	0	0	1	0	0	0
Pruritus	0	0	0	0	3	0	0	0	4	0	0	0
Acneiform rash	0	0	0	0	1	0	0	0	1	0	0	0
Maculopapular rash	0	0	0	0	3	0	0	0	3	0	0	0
Nasal mucositis	0	0	0	0	0	0	0	0	1	0	0	0
Vomiting	0	0	0	0	1	0	0	0	2	0	0	0