Table 1. The Demographic Data and Results of the Response to IAC in Retinoblastomaa.
| Patient Number | Age at the Time of DX(mo) | Group | Vitreous Seeds Before IAC | Previous Local Therapy | Number of IAC Cycles | The Used Drugs in IAC | Tumor Control Achieved | Complications | Vitreous Seeds Response After IAC | New Vitreous Seed After IAC | IVM (during TX) | Enucleation | Reason for Enucleation | Pathologic Findings in the Enucleated Eye | Follow Up |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 6 | C | 1 | Cryo, TTT | 1 | 1 | No response | - | No response | 0 | 1 | 1 | Unresponsive to TX | Poorly differentiated | 36 |
| 2 | 2.5 | D | 1 | Cryo, TTT | 2 | 1,3 | Complete | Vit hemo | NE | 1 | 0 | 24 | |||
| 3 | 48 | D | 1 | Cryo, TTT | 1 | 1,1 | Complete | Preret hemo | Incomplete response | 1 | 1 | 32 | |||
| 4 | 60 | D | 1 | Cryo, TTT | 1 | 1 | Partial | NVG, anterior segment involvement, ptosis | Incomplete response | 0 | 0 | 1 | NVG | Poorly differentiated | 57 |
| 5 | 0.5 | D | 1 | Cryo, TTT | 2 | 1,2 | Partial | - | Incomplete response | 1 | 1 | 1 | Unresponsive to TX | Poorly differentiated | 35 |
| 6 | 9 | D | 1 | Cryo, TTT | 1 | 1 | Complete | - | Incomplete response | 0 | 0 | 21 | |||
| 7 | 6 | D | 1 | Cryo, TTT | 1 | 1 | Partial | Vit hemorrhage, total hyphema | NE | 0 | 0 | 1 | Total hyphema | Poorly differentiated | 24 |
| 8 | 7 | E | 1 | Cryo, TTT, Photocoag | 1 | 2 | Partial and recurrence | - | Incomplete response | 1 | 1 | 3 | |||
| 9 | 6 | E | 1 | Cryo,TTT,Photocoag | 1 | 1 | Partial | Vit hemo | No response | 0 | 1 | 1 | Anterior segment involvement | Poorly differentiated | 18 |
| 10 | 4 | D | 0 | Cryo, TTT | 2 | 1,1 | Partial and recurrence | Vit hemo | No response | 1 | 1 | 1 | New tumor developmental and impossible more IAC | Well differentiated | 31 |
| 11 | 2.1 | D | 0 | TTT | 1 | 1 | Complete | Vit hemo, CRAO,cyclitic membrane,phthisis | NE | 0 | 0 | 1 | 22 | ||
| 12 | 2.8 | C | 1 | Cryo, TTT | 1 | 2 | No response | Vit hemo | Incomplete response | 1 | 0 | 1 | Unresponsive to TX | Poorly differentiated | 5 |
| 13 | 4 | D | 1 | Cryo, TTT, subtenon | 2 | 1,2 | Complete | Preret hemo | No response | 1 | 1 | Poorly differentiated | 14 | ||
| 14 | 5 | D | 1 | - | 1 | 1 | Complete | Severe ch-ret atrophy+ temporary arteriolitis, vit hemo | Incomplete response | 0 | 1 | 5 | |||
| 15 | 5 | D | 1 | TTT | 2 | 1 | Complete | Preret hemo, retinal fibrosis, RD | Incomplete response | 0 | 1 | 10 | |||
| 16 | 3.1 | D | 1 | IVM | 2 | 1,3 | Complete | CRAO, ch-ret atrophy, iris atrophy | No response | 1 | 1 | 17 | |||
| 17 | 2 | D | 1 | TTT | 1 | 1 | Partial | Vit hemo | Complete response | 1 | 0 | 4 | |||
| 18 | 3.6 | D | 0 | TTT | 2 | 2,2 | Complete | - | Incomplete response | 1 | 1 | 12 | |||
| 19 | 2 | D | 1 | Cryo, TTT | 1 | 1 | Complete | Severe ch -ret atrophy, ptosis | Incomplete response | 1 | 1 | 15 | |||
| 20 | 3 | E | 1 | TTT | 1 | 1 | Complete | - | Incomplete response | 0 | 0 | 3 | |||
| 21 | 4 | B | 1 | Cryo, TTT | 1 | 1 | Complete | Ch ret atrophy,RD | Complete response | 1 | 1 | 14 | |||
| 22 | 1 | D | 0 | TTT | 2 | 1,1 | Partial and recurrence | Vit hemo,subret hemo,TRD | Incomplete response | 1 | 1 | 1 | Unresponsive to TX | Poorly differentiated | 11 |
| 23 | 4 | D | 0 | Cryo, TTT | 1 | 1 | Complete | - | NA | 0 | 0 | 6 | |||
| 24 | 2 | D | 1 | TTT | 2 | 1,2 | Complete | - | Incomplete response | 1 | 0 | 5 |
aAbbreviations: Ch-ret, chorioretinal; Ch-ret atrophy, chorioretinal atrophy; CRAO, central retinal artery occlusion; Cryo, cryotherapy; DX, diagnosis; IAC, intra-arterial chemotherapy; NVG, neovascular glaucoma; Photocoag, photocoagulation; Prere themo, pre retinal hemorrhage; NA, not applicable; NE, not evaluable; RD, retinal detachment; TRD, tractional retinal detachment; TTT, transpupillary thermotherapy; Vit hemo, vitreous hemorrhage; TX, treatment; TRD, tractional retinal detachment