Table 2.
Potential confounders and nuclear individual ancestry in Uruguayan controls
| % African (mean ± SD) | % Native American (mean ± SD) | % European (mean ± SD) | |
|---|---|---|---|
| Controls (N = 164) | |||
| Place of residence (N) | |||
| Montevideo (143) | 9.3 ± 7.8 | 15.3 ± 11.6 | 75.4 ± 14.7 |
| Rest of the country (21) | 8.1 ± 5.2 | 10.5 ± 7.2 | 81.4 ± 7.8 |
| p-value | 0.81 | 0.13 | 0.16 |
| Hospital (N) | |||
| Public (139) | 9.5 ± 7.8 | 15.5 ± 11.7 | 75.1 ± 14.8 |
| Private (25) | 7.4 ± 5.4 | 10.2 ± 7.0 | 82.4 ± 6.8 |
| p-value | 0.27 | 0.07 | 0.05 |
| Menopause (N) | |||
| Yes (91) | 8.6 ± 7.6 | 13.9 ± 10.7 | 77.5 ± 14.6 |
| No (69) | 10.2 ± 7.4 | 16.1 ± 12.0 | 73.7 ± 13.4 |
| p-value | 0.05 | 0.32 | 0.04 |
| Breast cancer in the family (N) | |||
| Yes (16) | 8.6 ± 5.9 | 16.0 ± 12.6 | 75.4 ± 15.0 |
| No (148) | 9.2 ± 7.6 | 14.5 ± 11.1 | 76.3 ± 14.1 |
| p-value | 0.78 | 0.70 | 0.81 |
| Education (N) | |||
| Primary school (53) | 10.0 ± 8.1 | 17.6 ± 12.3 | 72.5 ± 16.0 |
| Secondary school (71) | 9.9 ± 7.9 | 15.4 ± 10.9 | 74.7 ± 13.1 |
| University (40) | 6.7 ± 5.1 | 9.5 ± 8.5 | 83.8 ± 10.2 |
| p-value | 0.08 | 0.001 | <0.001 |
| Socioeconomic status (N) | |||
| Low (53) | 9.9 ± 8.1 | 16.7 ± 11.7 | 73.4 ± 15.6 |
| Medium (111) | 8.8 ± 7.2 | 13.7 ± 10.9 | 77.5 ± 13.3 |
| p-value | 0.41 | 0.07 | 0.13 |
| Age at recruitment (mean change in years per 25% ancestry increase, 95% CI) (N = 164) | −0.56 (−1.75, 0.63) | 0.08 (−1.17, 1.33) | 0.52 (−0.68, 1.73) |
| p-value | 0.36 | 0.90 | 0.39 |
| Age at first child (mean change in years per 25% ancestry increase, 95% CI) (N = 139) | −0.44 (−1.26, 0.39) | −0.91 (−1.78, −0.03) | 0.94 (0.11, 1.78) |
| p-value | 0.30 | 0.04 | 0.03 |
| Age at menopause (mean change in years per 25% ancestry increase, 95% CI) (N = 49)a | −0.94 (−1.90, 0.02) | −1.60 (−2.66, −0.54) | 1.43 (0.46, 2.40) |
| p-value | 0.05 | 0.004 | 0.01 |
aAge at menopause was calculated for women who were ≥ 55 years old and had undergone menopause naturally.