Table 3.

Association of nuclear and mitochondrial ancestry with breast cancer risk in Uruguayan women

Nuclear ancestry	OR a	95% CI	p-value
European	1.05	(0.85,1.30)	0.63
African	1.09	(0.89,1.33)	0.42
Native American	0.84	(0.68,1.04)	0.10
N	312
Mitochondrial ancestry	OR b	95% CI	p-value
European	Reference		0.25c
African	0.54	(0.22,1.33)	0.18
Native American	0.71	(0.42,1.20)	0.20
N	312
No H haplogroup	Reference
H haplogroup	1.99	(1.13,3.51)	0.02
N	312
No H haplogroup	Reference
H haplogroup	1.84	(0.97,3.51)	0.06
Nd	171

All regression models were adjusted for age, education and hospital. Mitochondrial ancestry regression models were additionally adjusted for European nuclear ancestry.

^aBreast cancer OR per 25% increase in ancestry.

^bBreast cancer OR for women carrying an African or Native American mitochondrial haplogroup compared to women carrying a European haplogroup, or women carrying a H haplogroup compared to those carrying a different haplogroup.

^cP-value for the model.

^dAnalysis restricted to women carrying a European mitochondrial haplogroup.