. 2014 Nov 5;7(2):130–140. doi: 10.4168/aair.2015.7.2.130

Table 1. Characteristics of the reviewed studies on SNPs in TLR genes and asthma risk.

Reference	Ethnicity	Age: Case/control	Gender	Gene	Polymorphism	Case	Control	Results
Lazarus 2003	European-American	Matched	Matched	TLR9	rs5743836 T/C	64	114	SA
Noguchi 2004	Japanese (Chinese)	Children/46.9	Matched	TLR2	c. -191 G>A	133	186	NS
					c. 597 T>C	133	188	NS
					c. 1350 T>C	134	190	NS
				TLR3	-7A	135	189	NS
					IVS3 +71 C>A	134	188	NS
					c. 1377 C>T	133	189	NS
				TLR9	c. 1635 G>A	132	189	NS
Tantisira 2004	African-American	Matched	Matched	TLR6	Ser249Pro C>T	56	97	SA
Lazarus 2004	European-American	Matched	Matched	TLR10	c.+1031 G>T	506	514	SA
Lazarus 2004	European-American	Matched	Matched	TLR10	c.+2322 A>G	505	513	SA
Yang 2004	English (Caucasian)	Matched	Matched	TLR4	rs4986790 A>G	320	184	NS
		Matched	Matched	TLR4	rs4986790 A>G	309	184	NS
		Matched	Matched	TLR4	rs4986790 A>G	185	184	NS
Hoffjan 2005	German (Caucasian)	38/59	Matched	TLR6	Ser249Pro C>T	68	212	NS
Hoffjan 2005	German (Caucasian)	9.5/59	Matched	TLR6	Ser249Pro C>T	132	212	NS
Smit 2007	Danish (Caucasian)	19.2/matched	Matched	TLR2	rs4696480 A>T	100	87	NS
					rs5743704 C>A	100	87	NS
					rs5743708 C>T	100	87	NS
				TLR4	rs4986790 A>G	100	87	NS
				TLR4	rs4986791 C>T	100	87	NS
Caravalho 2008	European (Caucasians)	57.6±11.8/not mentioned	Matched	TLR2	rs5743708 G>A	14	80	NS
				TLR4	rs4986790 A>G	14	80	NS
				TLR9	rs5743836 T>C	14	80	NS
Lachheb 2008	African Caucasian	10.5/8	Matched	TLR2	rs5743708 C>T	210	224	NS
				TLR4	rs4986790 A>G	210	224	NS
				TLR4	rs4986791 C>T	210	224	NS
				TLR9	rs5743836 T>C	210	224	SA
				TLR9	rs187084 T>C	210	224	NS
Larocca 2008	Venezuelan (American)	44.6±15.22/42.63±13.89	Matched	T LR4	rs4986790 A>G	100	100	NS
Larocca 2008	Venezuelan (American)	44.6±15.22/42.63±13.89	Matched	T LR4	rs4986791 C>T	100	100	NS
Bjørnvold 2009	Norwegian (Caucasian)	Children	Matched	TLR2	Rs3804100 T>C	108	494	SA
Bjørnvold 2009	Norwegian (Caucasian)	Children	Matched	TLR2	Rs3804099T>C	108	494	NS
Hseih 2009	Taiwanese (Asian)	7.2±2.4/Children	Matched	TLR4	rs10983755 A>G	117	60	NS
Hseih 2009	Taiwanese (Asian)	7.2±2.4/Children	Matched	TLR4	rs1927914 C>T	117	60	NS
Zhang 2009	Chinese (Asian)	39.80±14.23/34.27±13.31	Male	TLR7/8	rs5935436 C>T	135	200	SA
					rs3761623 A>G	135	200	NS
					rs3764880 G>A	135	200	NS
		39.80±14.23/34.27±13.31	Female	TLR7/8	rs5935436 C>T	183	152	NS
					rs3761623 A>G	183	151	SA
					rs3764880 G>A	182	152	SA
Qian 2010	Chinese (Asian)	39.80/38.26	Matched	TLR1	rs4833095 C>T	318	351	NS
				TLR2	rs7656411 G>T	317	351	SA
				TLR6	rs5743831 A>G	318	352	NS
					rs5743808 T>C	318	351	NS
					rs2381289 C>T	318	352	NS
				TLR10	rs11466651 G>A	318	352	NS
					rs11466655 A>G	318	351	NS
					rs4504265 C>A	317	349	NS
Zhang 2011	Chinese (Asian)	39.80/38.26	Matched	TLR4	rs1927914 T>C	318	350	SA^*
					rs10983755 G>A	318	351
					rs11536879 A>G	304	348
					rs1927907 G>A	314	334
Palikhe 2011	Korean (Asian)	43.1±15.2/32.1±12.7	Matched	TLR3	rs3775296 G>T	254	274	NS
Palikhe 2011	Korean (Asian)	43.1±15.2/32.1±12.7	Matched	TLR3	rs3775291 G>A	254	274	NS
Vorvonko 2011	Russian (Caucasian)	Adults/38.5±10.4	Matched	TLR4	rs4986790 A>G	283	227	NS
Qian 2011	Chinese (Asian)	1.9-11.6/matched	Matched	TLR9	rs187084 C/T	312	339	NS
Hussein 2012	African Caucasian	8.4±2.6/10.1±2.3	Matched	TLR2	rs5743708 G>A	500	250	SA^*
Hussein 2012	African Caucasian	8.4±2.6/10.1±2.3	Matched	TLR4	rs4986790 A>G	500	251	SA^*
Şahin 2014	Turkish (Caucasian)	36±12.42/43±7.68	Matched	TLR4	rs4986790 A>G	131	75	NS
Şahin 2014	Turkish (Caucasian)	36±12.42/43±7.68	Matched	TLR4	rs4986791 C>T	131	75	SA

NS, non significant association; SA, significant association; SA^*, significant association with asthma severity.