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. 2014 Sep 17;26(3):692–714. doi: 10.1681/ASN.2014010028

Figure 5.

Figure 5.

The expression of VEGFA correlates with renal function. The expression of VEGFA is significantly lower (*P=0.025) in samples homozygous for A alleles (A/A; n=7) at the rs881585 locus compared with samples with minor alleles (A/G; n=7 or G/G; n=7) at this locus. (A) Only control samples (eGFR>85 ml/min per 1.73 m2) were used for the analysis. (B) Microarray-based transcript levels of VEGFA correlate with renal function in tubule samples (R2=0.219, P=1.7×10−6). (C) QRT-PCR–based VEGFA transcript levels (R2=0.228, P=7.8×10−4) confirm its correlation with kidney function. (D) VEGFA protein expression (by immunohistochemistry) correlates with transcript levels. Counterstained with hematoxylin. Scale bars, 50 μm.