Table 6.
Condition | Group 1 (n=89; IgA aB2GPI-Positive) | Group 2 (n=180; IgA aB2GPI-Negative) | P Value | ||
---|---|---|---|---|---|
N | Percent | N | Percent | ||
DGF | 25 | 28.1 | 26 | 14.4 | 0.01 |
Episodes of AR | 12 | 13.5 | 17 | 9.4 | 0.43 |
Graft loss | 34 | 38.2 | 46 | 25.6 | 0.05 |
Causes of graft loss | |||||
AR | 2 | 5.9 | 1 | 2.2 | 0.57 |
Uropathy | 0 | 0 | 1 | 2.2 | >0.99 |
Death | 13 | 38.2 | 28 | 60.9 | 0.08 |
Chronic allograft nephropathy | 8 | 23.5 | 12 | 26.1 | >0.99 |
Graft thrombosis | 8 | 23.5 | 0 | 0 | <0.001 |
Recurrence of disease. | 1 | 2.9 | 2 | 4.3 | >0.99 |
Others | 1 | 2.9 | 1 | 2.2 | >0.99 |
Death | 17 | 19.1 | 30 | 16.7 | 0.75 |
Causes of death | |||||
Stroke | 2 | 11.8 | 4 | 13.3 | >0.99 |
Heart failure | 1 | 5.9 | 0 | 0 | 0.36 |
Other cardiovascular disease | 2 | 11.8 | 2 | 6.7 | 0.61 |
Infection | 4 | 23.5 | 6 | 20.0 | >0.99 |
Cancer | 1 | 5.9 | 4 | 13.3 | 0.64 |
Sudden death | 1 | 5.9 | 3 | 10.0 | >0.99 |
Others | 6 | 35.3 | 9 | 30.0 | 0.75 |
Unknown | 0 | 0 | 2 | 6.7 | 0.53 |
Other complications | |||||
Patients with cancer | 12 | 13.5 | 22 | 12.2 | 0.92 |
Patients with cardiovascular events | 14 | 15.7 | 28 | 15.6 | 0.89 |
Immunosuppressant treatment | |||||
Calcineurin inhibitors | 87 | 97.8 | 178 | 98.8 | 0.85 |
CsAa | 40 | 44.9 | 39 | 21.7 | <0.001 |
TAC | 47 | 52.8 | 139 | 77.2 | <0.001 |
MMF | 84 | 94.4 | 166 | 92.2 | 0.69 |
Corticosteroids | 87 | 97.8 | 179 | 99.4 | 0.53 |
Sirolimus | 4 | 4.5 | 15 | 8.3 | 0.37 |
Treatment with CsA is a recipient age-dependent variable.