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. 2015 Feb 5;9:23. doi: 10.3389/fncel.2015.00023

Figure 1.

Figure 1

NMDA-induced LTD in distinct dendritic sub-regions of hippocampal CA1 neurons. (A) Schematic representation of transverse hippocampal CA1 lamina with test pulse stimulation electrode locations in proximal, distal and basal dendritic regions, and the recording electrode location for recording fEPSPs from the corresponding regions. The analog trace is a representative example of recorded potentials, and the scale is the same for all following panels. (B) Time course of the change in the slope of the fEPSP recorded from distal apical dendrites after induction of LTD by application of 30 μM NMDA for 5 min. Drug application is indicated with a black bar (n = 6). (C) Time course of the change in slope of the fEPSP recorded from proximal apical dendrites after NMDA-induced LTD. Black bar indicates the time NMDA was applied (n = 6). (D) Time course of the change in fEPSP slope recorded from basal dendrites after NMDA-induced LTD. Black bar indicates the time NMDA was applied (n = 7). (E) Comparison of NMDA induced LTD in distal, proximal and basal dendrites. The change in fEPSP is expressed as the percentage change from baseline. Analog traces represent typical fEPSPs from 30 min before (solid line) and 90 min after (dashed line) NMDA application. Scale bar for all analog traces is 5 mV/10 ms as shown in panel (A).