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. 2015 Feb 5;9:23. doi: 10.3389/fncel.2015.00023

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Copyright © 2015 Ramachandran, Ahmed and Dean.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of NMDA and low frequency stimulation (LFS)—induced LTD in distinct dendritic sub-regions of hippocampal CA1 neurons. (A) Time course of the change in the slope of the fEPSP recorded from distal apical dendrites after induction of LTD by application of 30 μM NMDA for 5 min (black circles, n = 6) or after induction of LTD by LFS (gray circles, n = 5). (B) Time course of the change in slope of the fEPSP recorded from proximal apical dendrites after NMDA-induced LTD (black circles, n = 6) or LFS-induced LTD (gray circles, n = 6). (C) Time course of the change in fEPSP slope recorded from basal dendrites after NMDA-induced LTD (black circles, n = 7) or LFS-induced LTD (gray circles, n = 4). (D) Comparison of LFS-induced LTD in distal, proximal and basal dendrites. The change in fEPSP is expressed as the percentage change from baseline. Analog traces represent typical fEPSPs from 30 min before (solid line) and 90 min after (dashed line) NMDA application or and LFS. Scale bar for all analog traces is 5 mV/10 ms as shown in panel (A).