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. 2015 Feb 5;9:23. doi: 10.3389/fncel.2015.00023

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Copyright © 2015 Ramachandran, Ahmed and Dean.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Time course of the change in the slope of the fEPSP recorded from distal apical dendrites after induction of LTD by application of 30 μM NMDA for 5 min. Drug application is indicated with a black bar. Ninety minutes after LFS LTD was induced (LFS, indicated by black arrow, n = 5). (B) Time course of the change in slope of the fEPSP recorded from distal apical dendrites in presence of NMDA (black circles, n = 6) or 50 uM picrotoxin (PTX) and NMDA gray circles (n = 4). The long lack bar indicates the time PTX was applied and the short bar indicates the time NMDA was applied. (C) Comparison of NMDA induced LTD in presence of PTX in distal dendrites. The change in fEPSP is expressed as the percentage change from baseline. (D) Time course of the change in slope of the fEPSP recorded from basal dendrites in presence of NMDA (black circles, n = 7) or 50 uM PTX and NMDA (gray circles, n = 4). The long lack bar indicates the time PTX was applied and the short bar indicates the time NMDA was applied. (E) Comparison of NMDA induced LTD in presence of PTX in basal dendrites. The change in fEPSP is expressed as the percentage change from baseline.