Figure 4.

Illustration of a closed-loop modulation protocol, recording and stimulating with two adjacent DBS electrode contacts in the STN, triggered by the ongoing oscillatory phase estimated on the basis of the PRC curve. To determine this precise timing, a closed-loop system will require a physiological calibration for each patient including the estimation of WPLI and PRC based on the individual vivo recordings. After this calibration, i.e., based on the subject-specific frequency range and the precise phase of maximum perturbation, the respective phase information will be the feedback signal to control the stimulation.