TABLE 1.
MICs and FICI values of AMB combined with ITZ, VCZ, ABZ, RVZ, and TBF against clinical isolates of Paecilomyces spp.a
| Strain | AMB-ITZ
|
AMB-VCZ
|
AMB-ABZ
|
AMB-RVZ
|
AMB-TBF
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MIC (μg/ml)
|
FICI | MIC (μg/ml)
|
FICI | MIC (μg/ml)
|
FICI | MIC (μg/ml)
|
FICI | MIC (μg/ml)
|
FICI | |||||||
| AMB | ITZ | AMB/ITZ | VCZ | AMB/VCZ | ABZ | AMB/ABZ | RVZ | AMB/RVZ | TBF | AMB/TBF | ||||||
| P. variotii 4647 | 2 | 4 | 0.5/2 | 0.7 | 0.5 | 2/0.03 | 1.1 | 0.5 | 2/0.03 | 1.1 | 0.12 | 0.12/0.12 | 1.1 | 8 | 2/0.12 | 1 |
| P. variotii 5516 | 0.12-0.25 | 4 | 0.12/1 | 0.7 | 16 | ND | ND | 2 | 0.12/0.5 | 0.7 | 4 | 0.12/2 | 1.5 | 8 | ND | ND |
| P. variotii 5517 | 0.12-0.25 | 4 | 0.12/2 | 1 | 8 | ND | ND | 1 | 0.12/0.5 | 1 | 2 | 0.25/0.25 | 1.1 | 8 | ND | ND |
| P. variotii 5518 | 0.12-0.25 | 1 | 0.25/0.03 | 1 | 2 | 0.12/0.03 | 0.5 | 0.5 | 0.12/0.06 | 0.6 | 0.25 | 0.12/0.25 | 2 | 8 | ND | ND |
| P. lilacinus 5519 | 16 | 32 | 16/32 | 2 | 4 | 0.12/4 | 1 | 4 | 0.12/4 | 1 | 1 | 0.12/1 | 1 | 8 | 0.12/4 | 0.5 |
| P. lilacinus 5522 | 16 | 32 | 16/32 | 2 | 2 | 0.12/2 | 1 | 4 | 8/0.12 | 0.5 | 0.25 | 0.12/0.5 | 2 | 4 | 0.12/4 | 1 |
| P. lilacinus 5540 | 16 | 32 | 16/32 | 2 | 4 | 0.12/4 | 1 | 4 | 0.12/4 | 1 | 0.5 | 0.12/1 | 2 | 4 | 0.12/4 | 1 |
a
ND, not determined.