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IC50s and Ki values of β-lactamase inhibitors for AmpCD and AmpCR
| β-Lactamase | Clavulanic acid
|
Sulbactam
|
Tazobactam
|
|||
|---|---|---|---|---|---|---|
| IC50 (μM) | Ki (μM) | IC50 (μM) | Ki (μM) | IC50 (μM) | Ki (μM) | |
| AmpCD | 19 ± 1 | 320 ± 30 | 3.9 ± 0.2 | 9.2 ± 0.2 | 1.4 ± 0.1 | 8.7 ± 2.4 |
| AmpCR | 140 ± 20 | 4,100 ± 1,600 | 24 ± 4 | 780 ± 150 | 25 ± 1 | 1,100 ± 120 |
