TABLE 4.
Contribution of resistance to individual antimicrobial agents to MDR phenotypes in clinical isolates of P. aeruginosa collected from 1999 to 2002
| Patient group, specimen source, or collection yra | % Isolates (no.)b that had an MDR phenotype | % of MDR isolates resistant to:
|
||||||
|---|---|---|---|---|---|---|---|---|
| Ceftazidime | Piperacillin-tazobactam | Ticarcillin-clavulanate | Gentamicin | Ciprofloxacin | Imipenem | Tobramycin | ||
| Patient type | ||||||||
| Non-ICU | 25.4 (6,526) | 52.8 | 47.7 | 83.3 | 58.6 | 77.9 | 44.7 | 45.4 |
| ICU | 29.5 (1,795) | 59.7 | 48.0 | 85.6 | 60.3 | 71.5 | 55.9 | 50.0 |
| OP | 19.4 (3,103) | 41.7 | 39.2 | 66.1 | 74.1 | 71.2 | 36.2 | 57.1 |
| NH | 29.9 (775) | 45.3 | 34.3 | 89.3 | 54.8 | 79.7 | 26.3 | 44.2 |
| All | 24.2 (12,199) | 50.5 | 44.7 | 79.6 | 62.6 | 75.4 | 43.0 | 49.0 |
| Patient age (yr) | ||||||||
| ≥18-39 | 29.0 (2,463) | 49.6 | 42.5 | 68.5 | 76.0 | 71.9 | 42.1 | 53.2 |
| 40-49 | 25.2 (1,290) | 52.9 | 46.7 | 80.5 | 58.5 | 74.8 | 50.8 | 46.4 |
| 50-59 | 27.2 (1,771) | 55.0 | 49.5 | 84.3 | 58.9 | 78.3 | 45.2 | 50.0 |
| 60-69 | 26.6 (1,817) | 54.2 | 49.9 | 86.2 | 54.0 | 76.8 | 48.9 | 43.0 |
| >70 | 21.5 (3,389) | 50.2 | 44.4 | 83.9 | 57.2 | 81.7 | 40.2 | 47.5 |
| All | 25.0 (10,730) | 51.9 | 46.0 | 80.4 | 61.4 | 77.2 | 44.2 | 48.3 |
| Specimen source | ||||||||
| Blood | 23.4 (443) | 54.6 | 47.2 | 82.4 | 65.5 | 78.3 | 55.1 | 56.2 |
| LRT | 31.3 (6,264) | 51.9 | 46.3 | 77.9 | 61.6 | 70.4 | 45.4 | 46.4 |
| URT | 5.8 (80) | 43.7 | 40.0 | 55.0 | 70.0 | 62.5 | 47.5 | 46.3 |
| Wound | 20.7 (2,434) | 56.8 | 51.4 | 84.9 | 56.3 | 75.5 | 43.2 | 46.0 |
| All | 26.0 (9,221) | 53.2 | 47.6 | 79.8 | 60.4 | 72.1 | 45.3 | 46.7 |
| Yr sample collected | ||||||||
| 1999 | 22.7 (1,462) | 55.1 | 55.9 | 78.5 | 60.3 | 67.0 | 40.9 | 43.4 |
| 2000 | 24.9 (2,536) | 51.6 | 50.3 | 76.5 | 69.8 | 71.1 | 46.2 | 53.1 |
| 2001 | 26.2 (4,366) | 48.5 | 40.8 | 78.8 | 64.7 | 77.1 | 41.4 | 52.7 |
| 2002 | 24.5 (4,753) | 47.2 | 39.5 | 82.0 | 59.6 | 80.8 | 46.0 | 47.6 |
| All | 24.9 (13,117) | 49.4 | 43.9 | 79.5 | 63.4 | 76.2 | 43.9 | 49.9 |
a
Abbreviations: OP, outpatients; NH, nursing home; LRT and URT, lower and upper respiratory tract, respectively.
b
Total percentage and number of isolates associated with MDR (resistance to ≥3 of the 10 antimicrobial agents).