FIG. 4.

Effect of oral phage on the inoculated E. coli strain in axenic mice. (A) Fecal E. coli counts (solid line in log CFU per milliliter) and fecal phage counts (dashed line in log PFU per milliliter) in two axenic mice exposed to the specified E. coli strains, phage JS94.1, or water at the specified time points; the start day is indicated with an arrow below the abscissa. A black line with squares or a gray line with triangles identifies values from an individual mouse. (B) 10⁶ PFU/ml was given from day 1 in the drinking water to axenic mice lacking intestinal bacteria. The mice were force-fed with 10⁴ CFU of K803 at day 8. Logarithmic fecal cell (solid line) and phage counts (dashed line) per gram of stool were plotted over 10 days. A black line with squares or a gray line with triangles identifies values from an individual mouse.