Figure 3.

Effect of treatment with Lipofundin, Smoflipid, or Clinoleic on lung inflammation during LPS-induced endotoxemia. Lethal endotoxemia was induced by Escherichia coli LPS (serotype 055:B5, 40 mg/kg i.p.) and treated with 2 g/kg Clinoleic (b), Lipofundin (c), Smoflipid (d), or normal saline (control, (a)) at 0.5, 8, and 24 h after LPS challenge. Lungs were harvested 24 h after LPS challenge and prepared as 3 μm paraffin-embedded sections for H&E staining. Representative micrographs are shown for at least three mice per group. Arrows indicate infiltrating neutrophils. Reference bar for (a)–(d) is shown in (b) and represents 30 μm.