Table 3.

Patient demographics and independent variables

	n = 2662	Unadjusted odds ratio (95% CI)	p-value
Mean Age ± SD (range) years	45 ± 13 (18 to 70)	1.00 (0 .99 to 1.01)	0.85
Male (%)	884 (33.2)	1
Female (%)	1778 (66.8)	1.03 (0.86 to 1.23)	0.734
Deprivation (%)
SIMD quintile 1(least deprived)	248 (9.3)	1
SIMD quintile 2	322 (12.1)	1.17 (0.80 to 1.72)	0.41
SIMD quintile 3	167 (6.3)	1.67 (1.08 to 2.58)	0.021
SIMD quintile 4	522 (19.6)	1.38 (0.98 to 1.94)	0.068
SIMD quintile 5 (most deprived)	1364 (51.2)	1.55 (1.11 to 2.16)	0.009
SIMD unknown (not in model)	39 (1.5)
†Co-morbidities (%)
0	1728 (64.9)	1
1	665 (25.0)	1.10 (0.90 to 1.33)	0.356
≥2	269 (10.1)	1.18 (0.90 to 1.54)	0.238
Current Smoking Status (%)
Non-smoker	1581 (59.4)	1
Smoker	1050 (39.4)	1.13 (0.95 to 1.34)	0.165
Smoking status unknown (not in model)	31 (1.2)
SSRI use (%)
ADM for <2 y (%)	1909 (71.7)	1
Same ADM for ≥2 y	753 (28.3)	1.80 (1.49 to 2.17)	<0.001
Practice (% practice pop.)
1	82 (2.2)	1
2	265 (2.7)	1.98 (1.09 to 3.57)	0.024
3	242 (3.6)	1.26 (0.68 to 2.35)	0.461
4	191 (4.4)	3.26 (1.77 to 5.99)	<0.001
5	372 (6.5)	1.50 (0.84 to 2.69)	0.171
6	201 (5.9)	2.69 (1.47 to 4.94)	0.001
7	224 (5.7)	2.20 (1.21 to 4.01)	0.01
8	322 (6.4)	1.81 (1.01 to 3.24)	0.047
9	181 (5.8)	3.80 (2.06 to 7.01)	<0.001
10	302 (8.0)	2.32 (1.29 to 4.18)	0.005
11	280 (9.3)	3.54 (1.96 to 6.38)	<0.001

Odds ratio: unadjusted. CI: 95% confidence interval. SD: standard deviation. SIMD: Scottish Index of Multiple Deprivation. SSRI: selective serotonin re-uptake inhibitor. ADM: antidepressant medicine.

^†Co-morbidities: Individuals had one or more of the following: asthma, COPD, cardiovascular disease, stroke, diabetes mellitus and/or hypertension.