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. 2015 Jan 30;19(1):28. doi: 10.1186/s13054-015-0750-y

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© Udy et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Probability of target attainment with varying creatinine clearance. Graphs depict the probability (%) of attaining 50% (A) and 100% (B) time above the minimum inhibitory concentration (fT_>MIC) following a 4.5 g piperacillin-tazobactam dose administered every 6 hours as an intermittent 20-minute infusion, and CLCR values. Varying minimum inhibitory concentrations (MIC) are displayed: 2 mg/L (black diamonds), 4 mg/L (grey diamonds), 8 mg/L (black squares), 16 mg/L (grey squares), 32 mg/L (black circles), and 64 mg/L (grey circles).