Table 2.
Mean parameter estimates and bootstrap mean (95% confidence interval) estimates for the final population pharmacokinetic model a
| Parameter | Model | Bootstrap | |||
|---|---|---|---|---|---|
| Mean | Mean | 95% confidence interval | |||
| 2.5% | 97.5% | ||||
| Fixed effects | |||||
| CL (L/hr) | 16.3 | 16.2 | 14.0 | 18.9 | |
| Vc (L) | 19.9 | 15.9 | 0.7 | 27.8 | |
| Vp (L) | 18.8 | 21.3 | 11.1 | 32.3 | |
| Q (L/h) | 37.3 | 42.9 | 22.0 | 73.3 | |
| ALAG (hr) | 0.8 | 0.13 | 0.01 | 0.31 | |
| Random effects BSV (% CV) | |||||
| CL (L/hr) | 56.0 | 55.3 | 45.2 | 65.4 | |
| Vc (L) | 29.6 | 23.5 | 0.2 | 45.7 | |
| Vp (L) | 67.6 | 69.2 | 24.6 | 158.4 | |
| ALAG (hr) | 0.3 | 0.4 | 0.05 | 0.8 | |
| Random error | |||||
| RUV (% CV) | 1.0 | 1.3 | 0.3 | 3.1 | |
| RUV (SD, mg/L) | 0.3 | 0.3 | 0.2 | 0.4 | |
aALAG, Infusion lag time; BSV, Between-subject variability; CL, Clearance; CV, Coefficient of variation; Q, Intercompartmental clearance; RUV, Residual unexplained variability; SD, Standard deviation; Vc, Volume of the central compartment; Vp, Volume of the peripheral compartment.