TABLE 1.
pncA nucleotide and amino acid changes in PZA-resistant M. tuberculosis clinical isolates from Portugal
| Mutation site | Nucleotide change | Amino acid changea | No. of isolates |
|---|---|---|---|
| −11 | A→G | Mutation in promoter | 2 |
| 2 | T2C | Met1→Thr* | 1 |
| 137 | C137T | Ala46→Val | 1 |
| 152 | A152C | His51→Pro | 1 |
| 193 | A insertion | Frameshift | 1 |
| 212 | A212G | His71→Arg | 3 |
| 250 | C insertion | Frameshift* | 4 |
| 286 | A286G | Lys96→Glu | 3 |
| 290 | T insertion | Frameshift* | 1 |
| 359 | T359C | Leu120→Pro* | 13 |
| 374 | T374G | Val125→Gly* | 8 |
| 391 | GG insertion | Frameshift | 1 |
| 395 | G395A | Gly132→Asp | 1 |
| 406 | G406C | Asp136→His | 1 |
| 421 | C421T | Gln141Stop | 1 |
| 439 | CG insertion | Frameshift* | 3 |
| 476 | T476C | Leu159→Pro* | 5 |
| 511 | G511A | Ala171→Thr | 1 |