Table 1.

Clinical Staging Systems Used in Chronic Lymphocytic Leukemia (CLL)

Rai Staging System			Binet Staging System
Risk Group	Stage	Definition	Stage	Definition
Low Risk	0	Lymphocytosis with leukemia cells in the blood or marrow	A	Hemoglobin ≥ 10g/dL, platelets ≥ 100,000/µL, and lymphadenopathy in up to 2 sites
Intermediate Risk	1	Lymphocytosis with lymphadenopathy at any site	B	Hemoglobin ≥ 10g/dL, platelets ≥ 100,000/µL, and lymphadenopathy in 3 or more sites*
	2	Lymphocytosis with organomegaly, with or without lymphadenopathy
High Risk	3	Disease-related anemia	C	All patients who have hemoglobin < 10g/dL or platelets < 100,000/µL, regardless of lymphadenopathy
	4	Disease-related thrombocytopenia

^*Sites considered (bilateral involvement counts as one site): 1. Head and neck, including Waldeyer’s ring; 2. Axillae; 3. Groin; 4. Palpable spleen; 5. Palpable liver