Fig. 2. Micro-CT analysis of bone changes.

(A) The subchondral bone plate thickness was outlined (white shaded areas) separately from trabecular bone of the tibia using the contouring methods on the cortical regions and measured the same algorithm as used for determining Tb. Th. (B) The epiphysis of proximal tibia was selected as region of interest (outlined by white line).We were only interested in bone changes occurring in the epiphysis, i.e., area between the articular cartilage and the growth plate.