Table 2.
Prevalence of transmitted drug resistance by geographical region
| Region | No. participants | Transmitted Drug Resistance | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Any | NRTI | NNRTI | PI | ||||||
| N | % (95% CI)† | N | % (95% CI) | N | % (95% CI) | N | % (95% CI) | ||
| Total | 1,869 | 188 | 10.1 (8.7, 11.5) | 75 | 4.0 (3.2, 5.0) | 85 | 4.5 (3.6, 5.6) | 52 | 2.8 (2.1, 3.6) |
| United States | 405 | 51 | 12.6 (9.5, 16.2) | 15 | 3.7 (2.1, 6.0) | 34 | 8.4 (5.9, 11.5) | 8 | 2.0 (0.9, 3.9) |
| Australia | 97 | 17 | 17.5 (10.6, 26.6) | 9 | 9.3 (4.3, 16.9) | 4 | 4.1 (1.1, 10.2) | 5 | 5.2 (1.7, 11.6) |
| Asia | 75 | 6 | 8.0 (3.0, 16.6) | 2 | 2.7 (0.3, 9.3) | 3 | 4.0 (0.8, 11.2) | 2 | 2.7 (0.3, 9.3) |
| Europe | 1,292 | 114 | 8.8 (7.3, 10.5) | 49 | 3.8 (2.8, 5.0) | 44 | 3.4 (2.5, 4.5) | 37 | 2.9 (2.0, 3.9) |
| United Kingdom | 320 | 15 | 4.7 (2.6, 7.6) | 6 | 1.9 (0.7, 4.0) | 3 | 0.9 (0.2, 2.7) | 6 | 1.9 (0.7, 4.0) |
| Germany | 271 | 29 | 10.7 (7.3, 15.0) | 12 | 4.4 (2.3, 7.6) | 10 | 3.7 (1.8, 6.7) | 11 | 4.1 (2.0, 7.1) |
| Spain | 191 | 24 | 12.6 (8.2, 18.1) | 6 | 3.1 (1.1, 6.7) | 11 | 5.8 (2.9, 10.1) | 10 | 5.2 (2.5, 9.4) |
| France | 96 | 16 | 16.7 (9.8, 25.7) | 12 | 12.5 (6.6, 20.8) | 4 | 4.2 (1.1, 10.3) | 3 | 3.1 (0.6, 8.9) |
| Belgium | 88 | 5 | 5.7 (1.9, 12.8) | 3 | 3.4 (0.7, 9.6) | 2 | 2.3 (0.3, 8.0) | 0 | 0 (0, 4.1) |
| Greece | 92 | 8 | 8.7 (3.8, 16.4) | 3 | 3.3 (0.7, 9.2) | 8 | 8.7 (3.8, 16.4) | 0 | 0 (0, 3.9) |
| Other | 234 | 17 | 7.3 (4.3, 11.4) | 7 | 3.0 (1.2, 6.1) | 6 | 2.6 (0.9, 5.5) | 7 | 3.0 (1.2, 6.1) |
| p-value | Transmitted Drug Resistance | |||
|---|---|---|---|---|
| Any | NRTI | NNRTI | PI | |
| Comparing regions* | 0.01 | 0.09 | 0.001 | 0.35 |
| Comparing countries within Europe | 0.002 | 0.004 | 0.004 | 0.06 |
†
Confidence intervals defined using the Clopper-Pearson Method
TDR defined according to WHO classification (2009) plus E138K and T215N
Other countries in Europe with <50 patients: Austria, Czech Republic, Denmark, Estonia, Finland, Ireland, Israel, Italy, Luxembourg, Norway, Poland, Portugal, Sweden, Switzerland.
*
Comparing regions=United States, Europe, Australia and Asia