FIG. 1.

Oral treatment efficacy of BMS-433771 against RSV in the cotton rat (A) and in the mouse BALB/c (B) host models of infection. Animals were inoculated intranasally with the Long strain of RSV. The compound (50 mg/kg) was administered by oral gavage, either as a single dose given 1 h before RSV inoculation or as a 4-day b.i.d. regimen (25 mg/kg/dose) in which the first dose was given 1 h before virus inoculation. Treatment cohorts are shown on the abscissa; animals of the infection control group were virus inoculated but not treated with BMS-433771. The infectious RSV lung titers are shown on the ordinate as log₁₀ TCID₅₀ per gram of lung. Each data point symbol represents the RSV titer for each individual animal of the respective treatment cohort. The horizontal line, drawn in each cohort, marks the geometric mean RSV titer of the group, with the viral titer number in parentheses. The horizontal hatched line, across the graph, represents the RSV titer at the limit of assay detection.