Table 1.

Proportion of children in the TONIC Trial with Dyslipidemia and Mean Lipid Levels(N=173)

	Baseline		96 Weeks
Lipid type and cutoff for dyslipidemia	Mean (95% CI)	Dyslipidemic N(%)	Mean (95% CI)	Dyslipidemic N(%)	P Value
Triglycerides, mg/dL   Dyslipidemic: ≥130 mg/dL	152.5 (137.5, 167.6)	87(50.3%)	165.0 (149.0, 180.9)	80(53.3%)	0.006
HDL, mg/dL   Dyslipidemic: <40 mg/dL	37.9 (36.6, 39.2)	107(61.8%)	35.1 (33.9, 36.3)	110(73.3%)	<0.001
Total cholesterol,mg/dL   Dyslipidemic: ≥200 mg/dL	176.3 (170.3,182.4)	41(23.7%)	169.8 (163.6,175.9)	25(16.7%)	0.02
LDL, mg/dL   Dyslipidemic: ≥130 mg/dL	108.8 (104.3,113.4)	37(21.5%)	103.4 (98.2,108.7)	26(17.9%)	0.004
Non-HDL-C, mg/dL   Dyslipidemic: ≥145 mg/dL	138.5 (132.6,144.3)	61(35.2%)	134.6 (128.6,140.7)	54(36.0%)	0.15
Triglycerides/HDL   Combined dyslipidemia of obesity: >3.0	4.3 (3.8, 4.8)	99(57.2%)	5.0 (4.4, 5.5)	103(59.5%)	<0.001

Adapted from the National Heart, Lung and Blood Institute(NHLBI) Expert Panel Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents.¹