Table 3.
Resolution of NASH at 96 weeks |
||||
---|---|---|---|---|
Mean(95% CI) | Resolved (N=52) |
Not resolved (N=69) |
P* | Adjusted P† |
Non HDL-C(mg/dL) | ||||
Baseline | 137.3(127.4,147.2) | 140.1(130.9,149.2) | 0.69 | 0.71 |
96 weeks | 130.0(120.1,139.9) | 141.2(131.7,150.7) | 0.11 | 0.05 |
Change from baseline | −7.3(−14.9,0.2) | 1.1(−5.7,7.9) | 0.1 | 0.01 |
Triglycerides(mg/dL) | ||||
Baseline | 139.7(113.7, 165.7) | 152.5(127.4, 177.5) | 0.49 | 0.72 |
96 weeks | 161.4(132.3,190.6) | 171.4(148.0,194.7) | 0.59 | 0.3 |
Change from baseline | 21.7(−2.2,45.6) | 18.9(−1.7,39.5) | 0.86 | 0.28 |
HDL(mg/dL) | ||||
Baseline | 39.1(36.7,41.6) | 36.5(34.3,38.7) | 0.12 | 0.09 |
96 weeks | 36.4(34.5,38.4) | 34.5(32.8,36.2) | 0.14 | 0.07 |
Change from baseline | −2.7(−4.5,−0.8) | −2.0(−3.6,−0.4) | 0.56 | 0.42 |
LDL(mg/dL) | ||||
Baseline | 110.8(101.5,120.2) | 109.0(102.5,115.4) | 0.73 | 0.97 |
96 weeks | 99.8(90.6,109.1) | 107.7(99.5,115.8) | 0.21 | 0.16 |
Change from baseline | −11.2(−19.1,−3.3) | −2.1(−7.6,3.4) | 0.05 | 0.06 |
Total cholesterol(mg/dL) | ||||
Baseline | 176.4(166.0, 186.9) | 176.6(166.8, 186.3) | 0.99 | 0.96 |
96 weeks | 166.4(156.5, 176.3) | 175.7(165.8, 185.6) | 0.2 | 0.11 |
Change from baseline | −10.0(−18.0,−2.0) | −0.9(−8.0,6.3) | 0.09 | 0.02 |
Triglycerides/HDL | ||||
Baseline | 4.0(3.0,5.0) | 4.4(3.7,5.1) | 0.48 | 0.62 |
96 weeks | 4.8(3.8,5.9) | 5.1(4.4,5.7) | 0.69 | 0.31 |
Change from baseline | 0.9(0.2,1.5) | 0.7(0.04,1.3) | 0.72 | 0.35 |
P-values derived from univariable linear regression models.
Adjusted p-values derived from linear regression models and included treatment group, baseline BMI, ethnicity, and for change measures, the baseline value of the lipid measure