TABLE 1.
Antifungal susceptibilities of 36 M. mycetomatis clinical isolates
Isolate | MIC (mg/liter)a:
|
|||||
---|---|---|---|---|---|---|
AMB
|
ITC
|
|||||
XTT assay at reduction indicated
|
NCCLS modified | XTT assay at reduction indicated
|
NCCLS modified | |||
>50% | >80% | >50% | >80% | |||
mm71 | 0.13 | 0.13 | 0.13 | 0.03 | 0.06 | 0.13 |
p2 | 0.13 | 0.13 | 0.13 | 0.06 | 0.13 | 0.25 |
mm46 | 0.13 | 0.13 | 0.25 | 0.01 | 0.01 | 0.01 |
mm54 | 0.13 | 0.25 | 0.5 | 0.01 | 0.01 | 0.03 |
mm30 | 0.13 | 0.5 | 0.5 | 0.13 | 1 | 0.5 |
mm49 | 0.13 | 0.5 | 0.5 | 0.01 | 0.01 | 0.06 |
mm58 | 0.13 | 0.5 | 1 | 0.06 | 0.13 | 0.06 |
mm63 | 0.25 | 0.25 | 0.25 | 0.03 | 0.03 | 0.06 |
mm39 | 0.25 | 0.5 | 0.25 | 0.06 | 0.06 | 0.06 |
mm36 | 0.25 | 0.5 | 0.5 | 0.06 | 0.06 | 0.06 |
mm41 | 0.25 | 0.5 | 0.5 | 0.06 | 0.13 | 0.13 |
mm83 | 0.25 | 0.5 | 0.5 | 0.03 | 0.06 | 0.06 |
mm22 | 0.25 | 0.5 | 1 | 0.06 | 0.13 | 0.13 |
mm14 | 0.5 | 0.5 | 0.5 | 0.06 | 0.13 | 0.13 |
mm28 | 0.5 | 0.5 | 0.5 | 0.06 | 0.13 | 0.06 |
mm10 | 0.5 | 0.5 | 1 | 0.25 | 1 | 1 |
mm29 | 0.5 | 0.5 | 1 | 0.03 | 0.06 | 0.06 |
mm25 | 0.5 | 1 | 0.5 | 0.06 | 0.13 | 0.06 |
mm18 | 1 | 1 | 1 | 0.01 | 0.03 | 0.01 |
mm55 | 1 | 1 | 1 | 0.06 | 0.25 | 0.25 |
mm50 | 1 | 1 | 2 | 0.01 | 0.03 | 0.03 |
mm52 | 1 | 1 | 4 | 0.06 | 0.5 | 0.5 |
mm26 | 1 | 2 | 1 | 0.06 | 0.25 | 0.25 |
mm72 | 1 | 2 | 1 | 0.06 | 0.06 | 0.03 |
mm78 | 1 | 2 | 1 | 0.06 | 0.06 | 0.06 |
mm43 | 1 | 2 | 2 | 0.13 | 0.25 | 0.25 |
mm64 | 1 | 2 | 2 | 0.03 | 0.03 | 0.06 |
mm68 | 1 | 2 | 2 | 0.06 | 0.5 | 0.5 |
p1 | 1 | 2 | 2 | 0.25 | 0.5 | 1 |
mm45 | 1 | 4 | 2 | 0.25 | 0.5 | 0.5 |
mm73 | 2 | 2 | 1 | 0.06 | 0.06 | 0.25 |
mm56 | 2 | 2 | 2 | 0.03 | 0.06 | 0.06 |
mm13 | 2 | 4 | 4 | 0.5 | 1 | 0.5 |
mm35 | 4 | 4 | 4 | 0.5 | 1 | 0.5 |
mm16 | 4 | 8 | 4 | 0.25 | 0.5 | 0.5 |
mm31 | 4 | 4 | 4 | 0.13 | 0.5 | 0.25 |
For the XTT assay, the concentrations resulting in more than 50% or 80% reduction in viable fungal mass are shown. For the NCCLS modified, the concentrations resulting in complete inhibition of fungal growth (MIC) are shown. Data are median values for three determinations.