FIG. 1.
Influence of the extracellular concentration of ciprofloxacin on its accumulation at equilibrium (2 h of incubation) in J774 macrophages. Regression parameters (sigmoidal dose-response with variable slope): r2 = 0.999 Hill's slope = 1:845, 50% effective concentrain (EC50) = 126.4 ± 1.0 μM. For this experiment (and for all those described in Figures 2 to 6 and 8), all data are the mean of at least three independent measurements ± standard deviation [SD] (when not visible, the SD bar is smaller than the symbol).