Fig. 6.

Organ-specific localization of ALDH1 and RALDH2 proteins revealed by immunohistochemistry. Analyses of E11.5 embryos sectioned coronally demonstrates ALDH1 protein in the medial portions of the otic vesicles and bilaterally in the thymic primordia (thy) (A), whereas RALDH2 is absent in these tissues (B). In sagittal sections of the E11.5 adrenal blastema, ALDH1 protein is detected (C), but not RALDH2 protein (D). At E14.5, sagittal sections through the developing kidney shows that ALDH1 protein is absent (E), but that RALDH2 protein is abundant and localized primarily in the renal cortex (F).