Table 3. Associations of BNIP3, p62 expression with clinicopathological parameters.
| Parameters | No. of cases (%) | BNIP3 in tumor | BNIP3 in stroma | Cytoplasmic p62 in tumor | Nuclear p62 in tumor | Nuclear p62 in stroma | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Negative (n = 75) (%) | Positive (n = 31) (%) | P-value | Negative (n = 90) (%) | Positive (n = 16) (%) | P-value | Negative (n = 39) (%) | Positive (n = 67) (%) | P-value | Negative (n = 68) (%) | Positive (n = 38) (%) | P-value | Negative (n = 72) (%) | Positive (n = 34) (%) | P-value | ||
| Age | 0.6696 | 1.0000 | 0.3191 | 1.0000 | 0.6829 | |||||||||||
| <61 years | 50(47.2) | 34(45.3) | 16(51.6) | 42(46.7) | 8(50.0) | 21(53.8) | 29(43.3) | 32(47.1) | 18(47.4) | 35(48.6) | 15(44.1) | |||||
| ≥61 years | 56(52.8) | 41(54.7) | 15(48.4) | 48(53.3) | 8(50.0) | 18(46.2) | 38(56.7) | 36(52.9) | 20(52.6) | 37(51.4) | 19(55.9) | |||||
| Gender | 1.0000 | 0.5883 | 0.6920 | 0.2229 | 0.6779 | |||||||||||
| Male | 57(53.8) | 40(53.3) | 17(54.8) | 47(52.2) | 10(62.5) | 22(56.4) | 35(52.2) | 40(58.8) | 17(44.7) | 40(55.6) | 17(50.0) | |||||
| Female | 49(46.2) | 35(46.7) | 14(45.2) | 43(47.8) | 6(37.5) | 17(43.6) | 32(47.8) | 28(41.2) | 21(55.3) | 32(44.4) | 17(50.0) | |||||
| Diabetes mellitus or hyperglycemia | 0.4975 | 0.7746 | 0.3969 | 0.3892 | 0.3810 | |||||||||||
| No | 35(33.0) | 23(30.7) | 12(38.7) | 29(32.2) | 6(37.5) | 15(38.5) | 20(29.9) | 20(29.4) | 15(39.5) | 26(36.1) | 9(26.5) | |||||
| Yes | 71(67.0) | 52(69.3) | 19(61.3) | 61(67.8) | 10(62.5) | 24(61.5) | 47(70.1) | 48(70.6) | 23(60.5) | 46(63.9) | 25(73.5) | |||||
| Tumor Size | 0.7892 | 0.5172 | 0.6150 | 0.6115 | 0.0173 | |||||||||||
| ≤2.0cm | 21(19.8) | 14(18.7) | 7(22.6) | 17(18.9) | 4(25.0) | 9(23.1) | 12(17.9) | 13(19.1) | 8(21.1) | 19(13.9) | 2(32.4) | |||||
| >2.0cm | 85(80.2) | 61(81.3) | 24(77.4) | 73(81.1) | 12(75.0) | 30(76.9) | 55(82.1) | 55(80.9) | 30(78.9) | 53(86.1) | 32(67.6) | |||||
| Tumor Location | 0.1791 | 0.0835 | 1.0000 | 0.8047 | 1.0000 | |||||||||||
| Head | 85(80.2) | 63(84.0) | 22(71.0) | 75(83.3) | 10(62.5) | 31(79.5) | 54(80.6) | 55(80.9) | 30(78.9) | 58(80.6) | 27(79.4) | |||||
| Body/tail | 21(19.8) | 12(16.0) | 9(29.0) | 15(16.7) | 6(37.5) | 8(20.5) | 13(19.4) | 13(19.1) | 8(21.1) | 14(19.4) | 7(20.6) | |||||
| Differentiation | 0.0155 | 0.2015 | 0.9109 | 0.2332 | 0.2560 | |||||||||||
| Well | 38(35.9) | 31(41.3) | 7(22.6) | 33(36.7) | 5(31.2) | 15(38.5) | 23(34.3) | 28(41.2) | 10(26.3) | 29(40.3) | 9(26.5) | |||||
| Moderate | 40(37.7) | 30(40.0) | 10(32.2) | 31(34.4) | 9(56.3) | 14(35.9) | 26(38.8) | 25(36.8) | 15(39.5) | 27(37.5) | 13(38.2) | |||||
| Poor | 28(26.4) | 14(18.7) | 14(45.2) | 26(28.9) | 2(12.5) | 10(25.6) | 18(26.9) | 15(22.0) | 13(34.2) | 16(22.2) | 12(35.3) | |||||
| Marginal status | 0.6055 | 0.0010 | 0.0132 | 0.8069 | 1.0000 | |||||||||||
| R0 | 83(78.3) | 60(80.0) | 23(74.2) | 76(84.4) | 7(45.8) | 25(64.1) | 58(86.6) | 54(79.4) | 29(76.3) | 56(77.8) | 27(79.4) | |||||
| R1 | 23(21.7) | 15(20.0) | 8(25.8) | 14(15.6) | 9(56.3) | 14(35.9) | 9(13.4) | 14(20.6) | 9(23.7) | 16(22.2) | 7(20.6) | |||||
| Nerve Infiltration | 0.7954 | 0.1830 | 0.2137 | 0.1390 | 0.4418 | |||||||||||
| Negative | 22(20.8) | 15(20.0) | 7(22.6) | 21(23.3) | 1(6.3) | 11(28.2) | 11(16.4) | 11(20.6) | 11(28.9) | 17(23.6) | 5(14.7) | |||||
| Positive | 84(79.2) | 60(80.0) | 24(77.4) | 69(76.7) | 15(93.7) | 28(71.8) | 56(83.6) | 57(79.4) | 27(71.1) | 55(76.4) | 29(85.3) | |||||
| Vascular invasion | 0.1358 | 0.3518 | 0.6336 | 0.3331 | 0.3207 | |||||||||||
| No | 24(22.6) | 14(18.7) | 10(32.3) | 19(21.1) | 5(31.3) | 10(25.6) | 14(20.9) | 13(19.1) | 11(28.9) | 14(22.2) | 10(29.4) | |||||
| Yes | 82(77.4) | 61(81.3) | 21(67.7) | 71(78.9) | 11(68.7) | 29(74.4) | 53(79.1) | 55(80.9) | 27(71.1) | 58(77.8) | 24(70.6) | |||||
| Lymphatic invasion | 0.8241 | 0.7823 | 1.0000 | 1.0000 | 0.6685 | |||||||||||
| Negative | 38(35.8) | 26(34.7) | 12(38.7) | 33(36.7) | 5(31.3) | 14(35.9) | 24(35.8) | 24(35.3) | 14(36.8) | 27(37.5) | 11(32.3) | |||||
| Positive | 68(64.2) | 49(65.3) | 19(61.3) | 57(63.3) | 11(68.7) | 25(64.1) | 43(64.2) | 44(64.7) | 24(63.2) | 45(62.5) | 23(67.6) | |||||
| UICC stage | 0.0649 | 0.2751 | 0.1719 | 0.8186 | 0.4797 | |||||||||||
| IA/IB/IIA | 28(26.4) | 16(21.3) | 12(38.7) | 22(24.4) | 6(37.5) | 7(17.9) | 21(31.3) | 19(27.9) | 9(23.7) | 21(29.2) | 7(20.6) | |||||
| IIB | 78(73.6) | 59(78.7) | 19(61.3) | 68(75.6) | 10(62.5) | 32(82.1) | 46(68.7) | 49(72.1) | 29(76.3) | 51(70.8) | 27(79.4) | |||||