Table 4. Associations of LC3, Beclin-1 expression with clinicopathological parameters.
| Parameters | No. of cases (%) | LC3 in tumor | LC3 in stroma | Cytoplasmic Beclin-1 in tumor | Nuclear Beclin-1 in tumor | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Negative (n = 43) (%) | Positive (n = 63) (%) | P-value | Negative (n = 87) (%) | Positive (n = 19) (%) | P-value | Negative (n = 80) (%) | Positive (n = 26) (%) | P-value | Negative (n = 75) (%) | Positive (n = 31) (%) | P-value | ||
| Age | 0.8440 | 0.8005 | 0.8226 | 1.0000 | |||||||||
| <61 years | 50(47.2) | 21(48.8) | 29(46.0) | 42(48.3) | 8(42.1) | 37(46.2) | 13(50.0) | 35(46.7) | 15(48.4) | ||||
| ≥61 years | 56(52.8) | 22(51.2) | 34(54.0) | 45(51.7) | 11(57.9) | 43(53.8) | 13(50.0) | 40(53.3) | 16(51.6) | ||||
| Gender | 0.1651 | 1.0000 | 0.4975 | 0.1370 | |||||||||
| Male | 57(53.8) | 27(62.8) | 30(47.6) | 47(54.0) | 10(52.6) | 45(56.2) | 12(46.2) | 44(58.7) | 13(41.9) | ||||
| Female | 49(46.2) | 16(37.2) | 33(52.4) | 40 (46.0) | 9(47.4) | 35(43.8) | 14(53.8) | 31(41.3) | 18(58.1) | ||||
| Diabetes mellitus or hyperglycemia | 0.0205 | 0.2869 | 0.4837 | 1.0000 | |||||||||
| No | 35(33.0) | 20(46.5) | 15(23.8) | 31(35.6) | 4(21.1) | 28(35.0) | 7(26.9) | 25(33.3) | 10(32.3) | ||||
| Yes | 71(67.0) | 23(53.5) | 48(76.2) | 56(64.4) | 15(78.9) | 52(65.0) | 19(73.1) | 50(66.7) | 21(67.7) | ||||
| Tumor Size | 0.0453 | 0.1125 | 1.0000 | 0.7892 | |||||||||
| ≤2.0cm | 21(19.8) | 13(30.2) | 8(12.7) | 20(23.0) | 1(5.3) | 16(20.0) | 5(19.2) | 14(18.7) | 7(22.6) | ||||
| >2.0cm | 85(80.2) | 30(69.8) | 55(87.3) | 67(77.0) | 18(94.7) | 64(80.0) | 21(80.8) | 61(81.3) | 24(77.4) | ||||
| Tumor Location | 0.3209 | 0.7592 | 1.0000 | 0.6041 | |||||||||
| Head | 85(80.2) | 37(86.0) | 48(76.2) | 69(85.1) | 16(57.9) | 64(80.0) | 21(80.8) | 59(78.7) | 26(83.9) | ||||
| Body/tail | 21(19.8) | 6(14.0) | 15(23.8) | 18(14.9) | 3(42.1) | 16(20.0) | 5(19.2) | 16(21.3) | 5(16.1) | ||||
| Differentiation | 0.0040 | < 0.0001 | 0.5450 | 0.3704 | |||||||||
| Well | 38(35.9) | 23(53.5) | 15(23.8) | 34(39.1) | 4(21.1) | 30(37.5) | 8(30.8) | 30(40.0) | 8(25.8) | ||||
| Moderate | 40(37.7) | 14(32.5) | 26(41.3) | 33(37.9) | 7(36.8) | 31(38.8) | 9(34.6) | 26(34.7) | 14(45.2) | ||||
| Poor | 28(26.4) | 6(14.0) | 22(34.9) | 20(23.0) | 8(42.1) | 19(23.7) | 9(34.6) | 19(25.3) | 9(29.0) | ||||
| Marginal status | 0.6338 | 0.0010 | 0.2722 | 0.0379 | |||||||||
| R0 | 83(78.3) | 35(81.4) | 48(76.2) | 74(85.1) | 9(47.4) | 65(81.3) | 18(69.2) | 63(84.0) | 20(64.5) | ||||
| R1 | 23(21.7) | 8(18.6) | 15(23.8) | 13(14.9) | 10(52.6) | 15(18.8) | 8(30.8) | 12(16.0) | 11(35.5) | ||||
| Nerve Infiltration | 0.1501 | 0.2187 | 0.5813 | 0.7954 | |||||||||
| Negative | 22(20.8) | 12(27.9) | 10(15.8) | 16(18.4) | 6(31.6) | 18(22.5) | 4(15.4) | 15(20.0) | 7(22.6) | ||||
| Positive | 84(79.2) | 31(72.1) | 53(84.1) | 71(81.6) | 13(68.4) | 62(77.5) | 22(84.6) | 60(80.0) | 24(77.4) | ||||
| Vascular invasion | 0.0044 | 0.0015 | 0.7896 | 0.4445 | |||||||||
| No | 24(22.6) | 16(37.2) | 8(12.7) | 14(16.1) | 10(52.6) | 19(23.8) | 5(19.2) | 19(25.3) | 5(16.1) | ||||
| Yes | 82(77.4) | 27(62.8) | 55(87.3) | 73(83.9) | 9(47.4) | 61(76.2) | 21(80.8) | 56(74.7) | 26(83.9) | ||||
| Lymphatic invasion | 0.0385 | 0.0633 | 0.0175 | 0.1883 | |||||||||
| Negative | 38(35.8) | 10(23.3) | 28(44.4) | 35(40.2) | 3(15.8) | 34(42.5) | 4(15.4) | 30(40.0) | 8(25.8) | ||||
| Positive | 68(64.2) | 33(76.7) | 35(55.6) | 52(59.8) | 16(84.2) | 46(57.5) | 22(84.6) | 45(60.0) | 23(74.2) | ||||
| UICC stage | 1.0000 | 1.0000 | 0.3103 | 0.4684 | |||||||||
| IA/IB/IIA | 28(26.4) | 11(25.6) | 17(27.0) | 23(26.4) | 5(26.3) | 19(23.8) | 9(34.6) | 18(24.0) | 10(32.3) | ||||
| IIB | 78(73.6) | 32(74.4) | 46(73.0) | 64(73.6) | 14(73.7) | 61(76.2) | 17(65.4) | 57(76.0) | 21(67.7) | ||||