Table 6. Mitochondrial function and autophagic status according to metabolic phenotype.
| Parameters | No. of cases (%) | Glucose-dependent metabolism | Glutamine-dependent metabolism | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Warburg type (n = 46) (%) | Reverse Warburg type (n = 15 (%) | Mixed type (n = 16) (%) | Null type (n = 29) (%) | P value | Canonical type (n = 18) (%) | Non-canonical type (n = 74) (%) | Mixed type(n = 5) (%) | Null type (n = 9) (%) | P-value | |||
| Tumor mitochondrial status | 0.2642 | 0.0999 | ||||||||||
| Dysfunctional | 31(29.2) | 12(26.1) | 7(46.7) | 6(37.5) | 6(20.7) | 8(44.4) | 17(23.0) | 1(20.0) | 5(55.6) | |||
| Functional | 75(70.8) | 34(73.9) | 8(53.3) | 10(62.5) | 23(79.3) | 10(55.6) | 57(77.0) | 4(80.0) | 4(44.4) | |||
| Stroma mitochondrial status | 0.1356 | 0.0046 | ||||||||||
| Dysfunctional | 16(15.1) | 4(8.7) | 5(33.3) | 2(12.5) | 5(17.2) | 3(16.7) | 6(8.1) | 3(60.0) | 4(44.4) | |||
| Functional | 90(84.9) | 42(91.3) | 10(66.7) | 14(87.5) | 24(82.8) | 15(83.3) | 68(91.9) | 2(40.0) | 5(55.6) | |||
| Tumor autophagic status | 0.0167 | 0.0034 | ||||||||||
| Activated | 57(53.8) | 30(65.2) | 3(20.0) | 7(43.7) | 17(58.6) | 5(27.8) | 44(59.5) | 5(100.0) | 3(33.3) | |||
| Nonactivated | 49(46.2) | 16(34.8) | 12(80.0) | 9(56.3) | 12(41.4) | 13(72.2) | 30(40.0) | 0(0) | 6(66.7) | |||
| Stroma autophagic status | 0.0002 | 0.1629 | ||||||||||
| Activated | 18(17.0) | 5(10.9) | 6(37.5) | 7(43.7) | 0(0) | 4(11.1) | 13(17.6) | 1(20.0) | 0(0) | |||
| Nonactivated | 88(83.0) | 41(89.1) | 10(62.5) | 9(56.3) | 29(100.0) | 14(88.9) | 61(82.4) | 4(80.0) | 9(100.0) | |||