Table 8. Univariate analysis of metabolism phenotypes in pancreatic cancers and overall survival by log-rank test.
| Metabolism phenotypes | Number of patients/death | Overall survival | |
|---|---|---|---|
| Mean survival(95% CI), months | P-value | ||
| Glucose-dependent metabolic status | 0.018 | ||
| Warburg type | 46/36 | 18(13 to 23) | |
| Reverse Warburg type | 15/11 | 30(21 to 40) | |
| Mixed type | 16/14 | 13(9 to 18) | |
| Null type | 29/18 | 27(19 to 36) | |
| Glutamine-dependent metabolic status | <0.001 | ||
| Canonical type | 18/14 | 31(23 to 39) | |
| Non-canonical type | 74/55 | 19(14 to 23) | |
| Mixed type | 5/5 | 6(4 to 8) | |
| Null type | 9/5 | 37(23 to 51) | |
| Categories of metabolism* | 0.021 | ||
| Glutamine-dependent metabolism | 26/17 | 29(21 to 41) | |
| Glucose-dependent metabolism | 6/4 | 37(22 to 45) | |
| Mixed type | 71/57 | 19(15 to 23) | |
| Null type | 3/1 | 51(39 to 65) | |
| No. of metabolism types # | <0.001 | ||
| Zero type | 3/1/ | 51(39 to 65) | |
| One type | 31/20 | 29(17 to 35) | |
| Two types | 53/41 | 21(16 to 26) | |
| Three types | 18/16 | 12(8 to 16) | |
| Four types | 1/1 | 3(3 to 3) | |
* Glutamine-dependent type (tumors only rely on glutamine-dependent metabolism), glucose-dependent type (tumors only rely on glucose-dependent metabolism), mixed type (tumors rely on both glucose- and glutamine-dependent metabolism), and null type (tumors show no sign of glucose- or glutamine-dependent metabolism)
#Metabolism types refer to cross combination among glucose- and glutamine-dependent metabolisms. Mixed types were composed of two main types of metabolism (i.e. Warburg effect and Reverse Warburg effect, Canonical type and Non-canonical type), and the null types were not composed of zero type in glucose- and glutamine-dependent metabolism (i.e. neither Warburg effect nor Rev erse Warburg effect, neither Canonical type nor Non-canonical type).