Table 3.
Multivariate proportional hazards model to predict biochemical recurrence in 3,226 men
| Variable | HR (95% CI) | p Value | |
|---|---|---|---|
| PSA (ng/ml): | |||
| 0–4.0 (referent) | 1.0 | ||
| 4.1–10.0 | 1.70 | (1.02, 2.83) | 0.0416 |
| 10.1–20.0 | 2.44 | (1.38, 4.32) | 0.0021 |
| Greater than 20.0 | 3.42 | (1.80, 6.52) | 0.0002 |
| Pathology stage: | |||
| Organ confined (referent) | 1.0 | ||
| Focal extraprostatic extension | 2.34 | (1.43, 3.85) | 0.0008 |
| Nonfocal extraprostatic extension | 3.57 | (2.42, 5.27) | < 0.0001 |
| Seminal vesicle involvement | 5.70 | (3.53, 9.20) | < 0.0001 |
| Lymph node metastasis | 5.82 | (3.24, 10.46) | < 0.0001 |
| Surgical margin status (pos vs neg) | 1.47 | (1.06, 2.04) | 0.0211 |
| Postop GS: | |||
| 6 or Less (referent) | 1.0 | ||
| 3 + 4 | 3.01 | (1.99, 4.56) | < 0.0001 |
| 4 + 3 | 6.82 | (4.38, 10.63) | < 0.0001 |
| 8 | 6.56 | (3.88, 11.07) | < 0.0001 |
| 9–10 | 18.45 | (10.38, 32.80) | < 0.0001 |
| TGC (yes vs no) | 1.45 | (1.04, 2.02) | 0.0285 |