Table 1.
Gene/Protein | All tumors |
Within genotype | ||||
---|---|---|---|---|---|---|
Akt | Myc | Wnt | Ras | Neu | ||
Glut1 mRNA | −0.077 | −0.323 | 0.166 | 0.227 | −0.426 | −0.562 |
Glut1 protein | 0.276 | 0.920 | −0.244 | −0.447 | −0.613 | 0.942 |
HK1 mRNA | −0.210 | −0.315 | −0.302 | −0.602 | 0.700 | −0.077 |
HK2 mRNA | 0.270 | 0.541 | 0.210 | 0.759 | −0.080 | 0.256 |
HK2 protein | 0.585 | 0.463 | 0.196 | 0.567 | −0.299 | 0.549 |
Glut4 protein | 0.119 | 0.311 | −0.148 | −0.556 | 0.190 | 0.414 |
p-mTOR | 0.191 | 0.141 | 0.015 | −0.194 | −0.549 | 0.754 |
p-S6 | 0.185 | 0.136 | 0.238 | 0.115 | 0.234 | 0.622 |
p-AMPK | − 0.355 | 0.879 | 0.332 | −0.490 | −0.719 | −0.693 |
PFK-1 mRNA | −0.176 | −0.131 | 0.226 | 0.693 | −0.199 | 0.224 |
PFK-2a mRNA | 0.385 | 0.733 | 0.086 | −0.151 | 0.041 | −0.051 |
PFK-2b mRNA | −0.369 | −0.363 | −0.666 | −0.116 | 0.674 | 0.273 |
Slc2a4 (Glut4) | −0.025 | 0.373 | −0.117 | −0.814 | −0.261 | −0.130 |
Slc5a1 (SLGT1) | −0.415 | −0.582 | −0.583 | − 0.788 | 0.161 | 0.263 |
Slc2a9 (Glut9) | −0.149 | −0.373 | 0.228 | 0.173 | −0.564 | 0.292 |
Slc2a8 (Glut8) | −0.163 | 0.137 | −0.680 | 0.059 | 0.389 | 0.004 |
Slc2a10 (Glut10) | −0.180 | − 0.790 | 0.252 | 0.001 | −0.131 | −0.124 |
Slc2a12 (Glut12) | −0.089 | −0.436 | −0.719 | 0.140 | 0.847 | −0.327 |
Slc2a6 (Glut6) | 0.059 | −0.453 | 0.129 | −0.012 | −0.472 | −0.159 |
p-PFK2b | −0.363 | −0.677 | −0.087 | −0.167 | 0.402 | −0.252 |
Proliferation (% Ki67+) |
0.401 | 0.130 | 0.002 | 0.173 | −0.097 | 0.222 |
HIF-1α | 0.344 | 0.564 | −0.210 | −0.522 | −0.472 | −0.089 |