FIG. 4.

Response patterns of six reporter strains. Reporter strains were induced as follows: the quinolone reporter strain (dinB) for 240 min (A), the fatty acid reporter strain (fabHB) for 200 min (B), the clindamycin reporter strain (expZ) for 300 min (C), the rifampin reporter strain (yvgS) for 80 min (D), the protein biosynthesis reporter strain (yrzI) for 360 min (E), and the glycopeptide reporter strain (ytrA) for 40 min (F). Compounds were added at concentrations just low enough not to inhibit growth of the organism (see Materials and Methods). Black bars show values for compounds that correctly elicited a signal. Grey bars show values for compounds that, as expected, did not show a signal significantly above that of the control sample. White bars indicate false-negatives, and checkered bars show values for compounds that elicited unexpected positive responses. Activities are given as relative light units (RLU). See text for abbreviations of drug names.