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. 2015 Feb 14;15:58. doi: 10.1186/s12885-015-1044-0

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© Tazzari et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Frequency of circulating mMDSCs and T cell function during sunitinib treatment. Histograms show the frequencies of CD14⁺HLADR^neg/low (mMDSCs) in live gated CD14⁺CD11b⁺ cells of patient’s PBMCs. Average level of mMDSC frequency of healthy donors (HD) is reported. Patient’s PBMCs were assayed for IFN-γ (red line) and IL-2 (blue line) production in response to overnight activation with anti-CD3/CD28-coated beads. Dotted horizontal lines (IFN-γ (red) and IL-2 (blue)) indicate the average level of cytokine-producing T cells in HD.