TABLE 1.
Genotypic and phenotypic data of 18 macrolide resistant S. pneumoniae isolates
| Number of isolates | Phenotype | Genotype | MIC (μg/mL) | |||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| E | Cd | C | A | P | Q/D | |||
| 1 | cMLSB | erm (B) | >256 | >256 | >256 | >256 | 0.016 | 0.5 |
| 2 | cMLSB | erm (B)+mef (A)/(E) | >256 | >256 | >256 | >256 | 0.5 | 2 |
| 3 | cMLSB | erm (B)+mef (A)/(E) | >256 | >256 | >256 | >256 | 1 | 0.5 |
| 4 | cMLSB | erm (B) | >256 | >256 | >256 | >256 | 1 | 0.75 |
| 5 | cMLSB | erm (B) | >256 | >256 | >256 | >256 | 1 | 1 |
| 6 | iMLSB+M | mef (A)/(E) | 4 | 0,125 | 6 | 24 | 0.75 | 0.38 |
| 7 | cMLSB | erm (B)+mef (A)/(E) | >256 | >256 | >256 | >256 | 1 | 1.5 |
| 8 | cMLSB | erm (B)+mef (A)/(E) | >256 | >256 | >256 | >256 | 1 | 2 |
| 9 | cMLSB | erm(B)+mef (A)/(E) | >256 | >256 | >256 | >256 | 1 | 0.75 |
| 10 | cMLSB | erm (B)+mef (A)/(E) | >256 | >256 | >256 | >256 | 2 | 1.5 |
| 11 | cMLSB | erm (B) | >256 | >256 | >256 | >256 | 0.23 | 2 |
| 12 | cMLSB | erm (B)+mef (A)/(E) | >256 | >256 | >256 | >256 | 2 | 2 |
| 13 | cMLSB | erm (B) | >256 | >256 | >256 | >256 | 1 | 1 |
| 14 | cMLSB | erm (B)+mef (A)/(E) | >256 | >256 | >256 | >256 | 1.5 | 1.5 |
| 15 | cMLSB | erm (B) | 16 | >256 | 6 | >256 | 0.016 | 0.5 |
| 16 | cMLSB | erm (B) | >256 | >256 | >256 | >256 | 1 | 0.75 |
| 17 | cMLSB | erm (B) | >256 | >256 | >256 | >256 | 2 | 0.75 |
| 18 | M | mef (A)/(E) | 24 | 0,094 | 24 | >256 | 1.5 | 0.38 |
E: erythromycin; Cd: clindamycin; C: clarithromycin; A: azithromycin; P: penicillin; Q/D: quinupristin/dalfopristin