Table 1. Changes in USA300 transcript levels of selected virulence factor-encoding genes in rabbit skin abscesses at 24 h post infection.
| Gene name/ ORF | Description | Fold change Day1/inoculum |
|---|---|---|
| isdB | Iron transport associated domain | 124.58 |
| hlgA | Hemolysin γ, S subunit | 20.8 |
| hlgC | Hemolysin γ, S subunit | 27.44 |
| hlgB | Hemolysin γ, F subunit | 76.31 |
| sbi | IgG-binding protein SBI | 24.12 |
| lukH | Leukocidin GH, S subunit | 8.19 |
| lukG | Leukocidin GH, F subunit | 5.24 |
| lukS-PV | PVL, S subunit | 12.74 |
| lukF-PV | PVL, F subunit | 6.64 |
| SAUSA300_1061 | Exotoxin (Exotoxin 3) | 35.5 |
| SAUSA300_0370 | Exotoxin (Enterotoxin) a | 9.3 |
| splB | Serine protease | 17.6 |
| splF | Serine protease | 4.4 |
| SAUSA300_0773 | Putative staphylocoagulase (vWbp) a | 34.52 |
| empbp | Extracellular matrix binding protein | 11.71 |
| efb | Fibrinogen-binding protein precursor | 5.31 |
| sdrE | Fibronectin-binding protein | 12.04 |
| cap1A | Chain length regulator (capsular polysaccharide biosynthesis) | 124.1 |
| clfA | Clumping factor A | -6.52 |
| SAUSA300_1052 | Fibrinogen-binding protein (Extracellular complement-binding protein/Ecb) a | 5.86 |
Microarray results are presented as the mean fold-change from 3 abscesses. Only transcripts with significant fold-change (P ≤ 0.05 and more than 2-fold change in transcriptome) are included.
aDetermined by BLASTProtein or BLASTGenomic available at http://www.ncbi.nlm.nih.gov.