Table 4. Subgroup and sensitivity analysis of the effect of the study design on IOP reduction.
| Study design | No.of studies | Weight | WMD (95%CI) | Heterogeity | overall effect | ||
|---|---|---|---|---|---|---|---|
| I2 | P | Z | P | ||||
| RCT | 2 | 100.0% | 1.47[-5.47,8.40] | 0% | 0.65 | 0.41 | 0.68 |
| Wilson (2003) | 55.1% | -1.01[-9.44,9.24 | |||||
| Pakrvan (2007) | 44.9% | 3.39[-6.96,13.74] | |||||
| Non-RCT | 4 | 100.0% | -6.22[-12.56,0.52] | 17% | 0.30 | 1.81 | 0.07 |
| Im (2004) | 11.6% | -12.20[-28.19,3.79] | |||||
| Lee (2008) | 18.3% | -10.92[-23.57,1.73] | |||||
| Tran (2009) | 38.70% | -6.55[-15.14,2.04] | |||||
| Shen (2011) | 13.6% | 5.80[-8.93,20.53] | |||||
RCT: prospective randomized controlled trial; Non-RCT: retrospective non—randomized controlled clinical trials; CI: confidence interval; WMD: weighted mean difference; IOP: intraocular pressure.