Table 11.
Combined targets of hsa-miR-181a-5p with experimental evidence based on both TarBase and miRTarBase 4.0
| Gene symbol | Full name | Alias | Function |
|---|---|---|---|
| ACOT12 | Acyl-CoA thioesterase 12 | CACH-1, Cach, STARD15, THEAL | Hydrolyzes acetyl-CoA to acetate and CoA |
| AFTPH | Aftiphilin | Nbla10388 | May play a role in membrane trafficking |
| AKAP12 | A kinase anchor protein 12 | AKAP250, SSeCKS | Anchoring protein that mediates the subcellular compartmentation of PKA and PKC |
| ALG10B | α-1,2-Glucosyltransferase | ALG10, KCR1 | Transfers glucose from dolichyl phosphate glucose onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol |
| AMMECR1 | Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 | RP13-360B22.1, AMMERC1 | |
| ANKRD1 | Ankyrin repeat domain 1 (cardiac muscle) | ALRP, C-193, CARP, CVARP, MCARP, bA320F15.2 | Plays an important role in endothelial cell activation |
| ANKRD13C | Ankyrin repeat domain 13C | RP4-677H15.5, dJ677H15.3 | |
| AP1M1 | Adaptor-related protein complex 1, mu 1 subunit | AP47, CLAPM2, CLTNM, MU-1A | Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network and endosomes |
| ARF6 | ADP-ribosylation factor 6 | Involved in protein trafficking | |
| ARHGAP11A | Rho GTPase activating protein 11A | RP11-1000B6.5, GAP (1–12) | GTPase activator activity |
| ARHGAP12 | Rho GTPase activating protein 12 | GTPase activator for the Rho-type GTPases, by converting them to an inactive GDP-bound state | |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | AIP1, ARL6IP, ARMER, SPG61 | May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation |
| ARL6IP6 | ADP-ribosylation factor-like 6 interacting protein 6 | RP23-265N10.1, 2310057C01Rik, 2610529A11Rik, Aip-6 | May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation |
| ATF7IP2 | Activating transcription factor 7 interacting protein 2 | MCAF2 | Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation |
| ATG10 | Autophagy related 10 | PP12616, APG10, APG10L, pp12616 | Plays a role in autophagy |
| ATM | ATM serine/threonine kinase | AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 | Serine/threonine protein kinase |
| ATP6V0E1 | ATPase, H+ transporting, lysosomal 9 kDa, V0 subunit e1 | ATP6H, ATP6V0E, M9.2, Vma21, Vma21p | Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | ATPASEII, ATPIA, ATPP2 | May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids |
| BAG2 | BCL2-associated athanogene 2 | RP3-496N17.2, BAG-2, dJ417I1.2 | Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release |
| BCL2 | B-cell CLL/lymphoma 2 | Bcl-2, PPP1R50 | Suppresses apoptosis |
| BCL2L11 | BCL2-like 11 | BAM, BIM, BOD | Induces apoptosis |
| BDNF | Brain-derived neurotrophic factor | ANON2, BULN2 | Promotes the survival of neuronal populations |
| BPGM | 2,3-bisphosphoglycerate mutase | DPGM | Plays a major role in regulating hemoglobin oxygen affinity |
| BRCA1 | Breast cancer 1, early onset | BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53 | Plays a central role in DNA repair by facilitating cellular response to DNA repair |
| BRIX1 | Biogenesis of ribosomes, homolog (S. cerevisiae) | BRIX, BXDC2 | Required for biogenesis of the 60S ribosomal subunit |
| BRMS1L | Breast cancer metastasis-suppressor 1-like | BRMS1 | Involved in the HDAC1-dependent transcriptional repression activity |
| BTBD3 | BTB (POZ) domain containing 3 | RP4-742J24.3, dJ742J24.1 | Acts as a key regulator of dendritic field orientation during the development of sensory cortex |
| C1orf109 | Chromosome 1 open reading frame 109 | ||
| C1orf43 | Chromosome 1 open reading frame 43 | HSPC012, NICE-3, NS5ATP4, S863-3 | |
| C1QTNF9 | C1q and tumor necrosis factor related protein 9 | 9130217G22Rik, CTRP9, Ciqtnf9 | Activates AMPK, AKT, and p44/42 MAPK signaling pathways |
| C8A | Complement component 8, α polypeptide | C8 is a constituent of the membrane attack complex | |
| CBX3 | Chromobox homolog 3 | HECH, HP1-GAMMA, HP1Hs-γ | Involved in transcriptional silencing in heterochromatin-like complexes |
| CCDC6 | Coiled-coil domain containing 6 | D10S170, H4, PTC, TPC, TST1 | Functions as a tumor suppressor |
| CCDC82 | Coiled-coil domain containing 82 | HT025, HSPC048 | |
| CCND1 | Cyclin D1 | BCL1, D11S287E, PRAD1, U21B31 | Essential for the control of the cell cycle at the G1/S (start) transition |
| CCNG1 | Cyclin G1 | CCNG | May play a role in growth regulation |
| CD46 | CD46 molecule, complement regulatory protein | AHUS2, MCP, MIC10, TLX, TRA2.10 | Acts as a cofactor for complement factor I |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (p27, Kip1) | CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | Important regulator of cell cycle progression |
| CDX2 | Caudal type homeobox 2 | CDX-3, CDX3 | Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium |
| CEP97 | Centrosomal protein 97 kDa | 2810403B08Rik, LRRIQ2 | Collaborates with cep110, being involved in the suppression of a cilia assembly program |
| CFI | Complement factor I | AHUS3, ARMD13, C3BINA, C3b-INA, FI, IF, KAF | Responsible for cleaving the α-chains of C4b and C3b, in the presence of the cofactors C4-binding protein and factor H, respectively |
| CHD1 | Chromodomain helicase DNA binding protein 1 | Sequence-selective DNA-binding protein | |
| CHL1 | Cell adhesion molecule L1-like | CALL, L1CAM2 | Plays a role in nervous system development and in synaptic plasticity |
| CHRFAM7A | CHRNA7 (cholinergic receptor, nicotinic, α 7, exons 5–10) and FAM7A (family with sequence similarity 7A, exons A–E) fusion | CHRNA7, CHRNA7-DR1, D-10 | Extracellular ligand-gated ion channel activity |
| CLUAP1 | Clusterin associated protein 1 | CFAP22, FAP22 | May play a role in cell proliferation or apoptosis |
| COL27A1 | Collagen, type XXVII, α 1 | RP11-82I1.1 | Plays a role during the calcification of cartilage and the transition of cartilage to bone |
| COPS2 | COP9 signalosome subunit 2 | ALIEN, CSN2, SGN2, TRIP15 | Involved in various cellular and developmental processes |
| CST5 | Cystatin D | Cysteine proteinase inhibitor | |
| CXorf1 | Transmembrane protein 257 | CXorf1 | |
| D3R | Dopamine receptor D3 | DRD3; D3DR; ETM1; FET1 | Inhibits adenylyl cyclase through inhibitory G-proteins, plays a role in cognitive and emotional functions |
| DCP2 | Decapping mRNA 2 | NUDT20 | Necessary for the degradation of mRNAs |
| DCST1 | DC-STAMP domain containing 1 | RP11-307C12.10-003 | Protein and zinc ion binding |
| DDIT4 | DNA-damage-inducible transcript 4 | RP11-442H21.1, Dig2, REDD-1, REDD1 | Inhibits cell growth by regulating the frap1 pathway upstream of the tsc1-tsc2 complex and downstream of Akt1 |
| DDX27 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 | HSPC259, DRS1, Drs1p, PP3241, RHLP, dJ686N3.1 | Probable ATP-dependent RNA helicase |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | DBX, DDX14, DDX3, HLP2 | ATP-dependent RNA helicase |
| DNAJC7 | DnaJ (HSP40) homolog, subfamily C, member 7 | DJ11, DJC7, TPR2, TTC2 | Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors |
| DSCR8 | Down syndrome critical region gene 8 | C21orf65, CT25.1a, CT25.1b, MMA-1, MMA-1a, MMA-1b, MMA1, MTAG2 | |
| DUSP5 | Dual specificity phosphatase 5 | DUSP, HVH3 | Displays phosphatase activity toward several substrates |
| DUSP6 | Dual specificity phosphatase 6 | HH19, MKP3, PYST1 | Inactivates MAP kinases |
| EIF1 | Eukaryotic translation initiation factor 1 | A121, EIF-1A, ISO1, SUI1, EIF1 | Necessary for scanning and involved in initiation site selection |
| EIF2C1 | Argonaute RISC catalytic component 1 | RP4-789D17.1, EIF2C, AGO1, GERP95, Q99 | Required for RNA-mediated gene silencing |
| EIF2C3 | Argonaute RISC catalytic component 3 | AGO3 | Required for RNA-mediated gene silencing |
| ELAVL1 | ELAV like RNA binding protein 1 | ELAV1, HUR, Hua, MelG | Binds avidly to the AU-rich element in FOS and IL3 mRNAs |
| ENAH | Enabled homolog | RP11-496N12.7, ENA, MENA, NDPP1 | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity |
| EP300 | E1A binding protein p300 | RP1-85F18.1, KAT3B, RSTS2, p300 | Functions as HAT and regulates transcription via chromatin remodeling |
| EPHA5 | EPH receptor A5 | CEK7, EHK-1, EHK1, EK7, HEK7, TYRO4 | Receptor for members of the ephrin-A family |
| ESR1 | Estrogen receptor 1 | RP1-130E4.1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | Nuclear hormone receptor |
| EYA4 | EYA transcriptional coactivator and phosphatase 4 | RP11-704J17.4, CMD1J, DFNA10 | Tyrosine phosphatase that specifically dephosphorylates “Tyr-142” of histone H2AX (H2AXY142ph) |
| FAM160A2 | Family with sequence similarity 160, member A2 | C11orf56 | |
| FAM222B | Family with sequence similarity 222, member B | C17orf63 | |
| FAM47B | Family with sequence similarity 47, member B | RP13-520K9.1 | |
| FAT1 | FAT atypical cadherin 1 | CDHF7, CDHR8, FAT, ME5, hFat1 | Could function as a cell-adhesion protein |
| FBXO11 | F-box protein 11 | UG063H01, FBX11, PRMT9, UBR6, VIT1 | Substrate recognition component of the SCF E3 ubiquitin-protein ligase complex |
| FBXO28 | F-box protein 28 | CENP-30, Fbx28 | Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation |
| FBXO33 | F-box protein 33 | BMND12, Fbx33, c14_5247 | Substrate recognition component of the SCF E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins |
| FBXO34 | F-box protein 34 | CGI-301, Fbx34 | Substrate-recognition component of the SCF E3 ubiquitin ligase complex |
| FKBP10 | FK506 binding protein 10 | PSEC0056, FKBP65, OI11, OI6, PPIASE, hFKBP65 | PPIases accelerate the folding of proteins during protein synthesis |
| FKBP4 | FK506 binding protein 4 | FKBP51, FKBP52, FKBP59, HBI, Hsp56, PPIase, p52 | May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors |
| FKBP7 | FK506 binding protein 7 | UNQ670/PRO1304, FKBP23, PPIase | PPIases accelerate the folding of proteins during protein synthesis |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | AP-1, C-FOS, p55 | Nuclear phosphoprotein, which forms a tight but noncovalently linked complex with the JUN/AP-1 transcription factor |
| FRA10AC1 | Fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 | PRO2972, C10orf4, F26C11.1-like, FRA10A | |
| FSIP1 | Fibrous sheath interacting protein 1 | HSD10 | |
| FXYD6 | FXYD domain containing ion transport regulator 6 | UNQ521/PRO1056 | |
| GADD45G | Growth arrest and DNA-damage-inducible, γ | RP11-260L6.1, CR6, DDIT2, GADD45γ, GRP17 | Involved in the regulation of growth and apoptosis |
| GANAB | Glucosidase, α; neutral AB | G2AN, GLUII | Cleaves sequentially the 2 innermost α-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins |
| GATA6 | GATA binding protein 6 | Regulates terminal differentiation and/or proliferation | |
| GATAD2B | GATA zinc finger domain containing 2B | RP11-216N14.6, MRD18, P66β, p68 | Has transcriptional repressor activity |
| GCNT1 | Glucosaminyl (N-acetyl) transferase 1, core 2 | RP11-214N16.1, C2GNT, C2GNT-L, C2GNT1, G6NT, NACGT2, NAGCT2 | Forms critical branches in O-glycans |
| GIGYF1 | GRB10 interacting GYF protein 1 | PP3360, GYF1, PERQ1 | May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling |
| GNA13 | G protein, α 13 | G13 | Modulators or transducers in various transmembrane signaling systems |
| GNAI3 | G protein, α inhibiting activity polypeptide 3 | RP5-1160K1.2, 87U6, ARCND1 | G proteins are involved as modulators or transducers in various transmembrane signaling systems |
| GNB1 | G protein, β polypeptide 1 | RP1-283E3.7 | A modulator or transducer in various transmembrane signaling systems |
| GPR137B | G protein-coupled receptor 137B | RP5-985L19.1, TM7SF1 | |
| GPR78 | G protein-coupled receptor 78 | UNQ5925/PRO19818 | Orphan receptor |
| GPR83 | G protein-coupled receptor 83 | GIR, GPR72 | Orphan receptor. Could be a neuropeptide y receptor |
| GPRIN3 | GPRIN family member 3 | GRIN3 | May be involved in neurite outgrowth |
| GSTM2 | Glutathione S-transferase mu 2 (muscle) | GST4, GSTM-2, GTHMUS, GSTM2 | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles |
| H1F0 | H1 histone family, member 0 | H10, H1FV | Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures |
| H2AFY | H2A histone family, member Y | H2A.y, H2A/y, H2AF12M, H2AFJ, MACROH2A1.1, mH2A1, macroH2A1.2 | Plays a central role in transcription regulation, DNA repair, DNA replication, and chromosomal stability |
| H3F3B | H3 histone, family 3B | H3.3B | Plays a central role in transcription regulation, DNA repair, DNA replication, and chromosomal stability |
| HDAC6 | Histone deacetylase 6 | JM21, CPBHM, HD6, PPP1R90 | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | E3 ubiquitin-protein ligase | |
| HEY2 | Hes-related family bHLH transcription factor with YRPW motif 2 | RP1-293L8.3, CHF1, GRIDLOCK, GRL, HERP1, HESR2, HRT2, bHLHb32 | Downstream effector of Notch signaling, which may be required for cardiovascular development |
| HIPK2 | Homeodomain interacting protein kinase 2 | PRO0593 | Protein kinase acting as a corepressor of several transcription factors |
| HMGB2 | High mobility group box 2 | HMG2 | Binds preferentially ssDNA and unwinds double stranded DNA |
| HNRNPAB | Heterogeneous nuclear ribonucleoprotein A/B | ABBP1, HNRPAB | Binds single-stranded RNA |
| HNRPDL | Heterogeneous nuclear ribonucleoprotein D-like | HNRNP, HNRPDL, JKTBP, JKTBP2, laAUF1 | Acts as a transcriptional regulator |
| HOOK3 | Hook microtubule-tethering protein 3 | HK3 | Probable cytoskeletal linker protein, involved in tethering the Golgi complex to the cytoskeleton |
| HOXA10 | Homeobox A10 | HOX1, HOX1.8, HOX1H, PL | Sequence-specific transcription factor |
| HOXA11 | Homeobox A11 | HOX1, HOX1I | Sequence-specific transcription factor |
| HRAS | Harvey rat sarcoma viral oncogene homolog | C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV1, RASH1, p21ras, HRAS | Ras proteins bind GDP/GTP and possess intrinsic GTPase activity |
| HSD17B3 | Hydroxysteroid (17-β) dehydrogenase 3 | RP11-240L7.3, EDH17B3, SDR12C2 | Favors the reduction of androstenedione to testosterone |
| HSP90B1 | Heat-shock protein 90 kDa β (Grp94), member 1 | ECGP, GP96, GRP94, HEL-S-125m, HEL35, TRA1 | Molecular chaperone that functions in the processing and transport of secreted proteins |
| HSPA13 | Heat-shock protein 70 kDa family, member 13 | STCH | Has peptide-independent ATPase activity |
| HSPA1B | Heat-shock 70 kDa protein 1B | DAAP-21F2.7, HSP70-1B, HSP70-2 | Stabilizes preexistent proteins against aggregation and mediates the folding of newly translated polypeptides in the cytosol as well as within organelles |
| HUWE1 | HECT, UBA and WWE domain containing 1 | RP3-339A18.4, ARF-BP1, HECTH9, HSPC272, Ib772, LASU1, MULE, URE-B1, UREB1 | E3 ubiquitin-protein ligase mediating ubiquitination and subsequent proteasomal degradation of target proteins. |
| ICMT | Isoprenylcysteine carboxyl methyltransferase | RP1-120G22.4, HSTE14, MST098, MSTP098, PCCMT, PCMT, PPMT | Catalyzes the posttranslational methylation of isoprenylated C-terminal cysteine residues |
| IDS | Iduronate 2-sulfatase | MPS2, SIDS | Required for the lysosomal degradation of heparan sulfate and dermatan sulfate |
| INCENP | Inner centromere protein antigens | Component of the chromosomal passenger complex, a complex that acts as a key regulator of mitosis | |
| IQCG | IQ motif containing G | CFAP122, DRC9 | |
| KAT2B | K(lysine) acetyltransferase 2B | CAF, P/CAF, PCAF | Functions as a HAT to promote transcriptional activation |
| KBTBD3 | Kelch repeat and BTB (POZ) domain containing 3 | BKLHD3 | |
| KBTBD7 | Kelch repeat and BTB (POZ) domain containing 7 | ||
| KCTD2 | Potassium channel tetramerization domain containing 2 | ||
| KCTD3 | Potassium channel tetramerization domain containing 3 | RP11-5F19.1, NY-REN-45 | |
| KIAA0100 | KIAA0100 | BCOX, BCOX1, CT101 | |
| KIAA0101 | KIAA0101 | L5, NS5ATP9, OEATC, OEATC-1, OEATC1, PAF, PAF15, p15(PAF), p15/PAF, p15PAF | May be involved in protection of cells from UV-induced cell death |
| KIAA1462 | KIAA1462 | JCAD | |
| KIAA2026 | KIAA2026 | ||
| KLF6 | Kruppel-like factor 6 | RP11-184A2.1, BCD1, CBA1, COPEB, CPBP, GBF, PAC1, ST12, ZF9 | Plays a role in B-cell growth and development |
| KLHL15 | Kelch-like family member 15 | HEL-S-305 | Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins |
| KLHL42 | Kelch-like family member 42 | Ctb9, KLHDC5 | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis |
| KLRC4 | Killer cell lectin-like receptor subfamily C, member 4 | NKG2-F, NKG2F | May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells |
| KRAS | Kirsten rat sarcoma viral oncogene homolog | C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS1, KRAS2, NS, NS3, RASK2, KRAS | Binds GDP/GTP and possesses intrinsic GTPase activity |
| LAMA3 | Laminin, α3 | BM600, E170, LAMNA, LOCS, lama3a | Binding to cells via a high-affinity receptor, mediating the attachment, migration, and organization of cells into tissues |
| LBR | Lamin B receptor | PRO0650, DHCR14B, LMN2R, PHA, TDRD18 | Anchors the lamina and the heterochromatin to the inner nuclear membrane. |
| LCLAT1 | Lysocardiolipin acyltransferase 1 | UNQ1849/PRO3579, 1AGPAT8, AGPAT8, ALCAT1, HSRG1849, LYCAT, UNQ1849 | Acyl-CoA: lysocardiolipin acyltransferase |
| LFNG | LFNG O-fucosylpeptide 3-β-N- acetylglucosaminyltransferase | SCDO3 | Glycosyltransferase |
| LGALSL | Lectin, galactoside-binding-like | HSPC159, GRP | Does not bind lactose and may not bind carbohydrates |
| LPGAT1 | Lysophosphatidylglycerol acyltransferase 1 | FAM34A, FAM34A1, NET8 | Lysophoshatidylglycerol-specific acyltransferase |
| LRRC17 | Leucine rich repeat containing 17 | UNQ3076/PRO9909, P37NB | Involved in bone homeostasis, acting as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors |
| LRRN3 | Leucine rich repeat neuronal 3 | Nbla10363, FIGLER5, NLRR-3, NLRR3 | |
| LYSMD3 | LysM, putative peptidoglycan-binding, domain containing 3 | ||
| MAP1B | Microtubule-associated protein 1B | FUTSCH, MAP5, PPP1R102 | May play a role in the cytoskeletal changes that accompany neurite extension |
| MAP2K1 | Mitogen-activated protein kinase kinase 1 | CFC3, MAPKK1, MEK1, MKK1, PRKMK1 | Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases |
| MAZ | MYC-associated zinc finger protein (purine-binding transcription factor) | PUR1, Pur-1, SAF-1, SAF-2, SAF-3, ZF87, ZNF801, Zif87 | May function as a transcription factor, with dual roles in transcription initiation and termination |
| MCL1 | Myeloid cell leukemia 1 | BCL2L3, EAT-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT, MCL1 | Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation |
| METAP1 | Methionyl aminopeptidase 1 | MAP1A, MetAP1A | Removes the amino-terminal methionine from nascent proteins |
| MFAP3 | Microfibrillar-associated protein 3 | Component of the elastin-associated microfibrils | |
| MGAT5 | Mannosyl (α-1,6-)-glycoprotein β1,6-N-acetyl- glucosaminyltransferase | GNT-V, GNT-VA | Catalyzes the addition of N-acetylglucosamine in β1-6 linkage to the α-linked mannose of biantennary N-linked oligosaccharides |
| MIF | Macrophage migration inhibitory factor (glycosylation-inhibiting factor) | GIF, GLIF, MMIF | The expression of MIF at sites of inflammation suggests a role for the mediator in regulating the function of macrophage in host defense. Also acts as a phenylpyruvate tautomerase |
| MOB1A | MOB kinase activator 1A | C2orf6, MATS1, MOB1, MOBK1B, MOBKL1B, Mob4B | Activator of LATS1/2 in the Hippo signaling pathway |
| MOB1B | MOB kinase activator 1B | MATS2, MOB4A, MOBKL1A | Activator of LATS1/2 in the Hippo signaling pathway |
| MOB3B | MOB kinase activator 3B | C9orf35, MOB1D, MOBKL2B | May regulate the activity of kinases |
| MRPS14 | Mitochondrial ribosomal protein S14 | DJ262D12.2, HSMRPS14, MRP-S14, S14mt | |
| MTMR12 | Myotubularin related protein 12 | 3-PAP, PIP3AP | Inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location |
| MTMR3 | Myotubularin related protein 3 | hCG_2011013, FYVE-DSP1, ZFYVE10 | Phosphatase that acts on lipids with a phosphoinositol head group |
| MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | MSR, cblE | Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state |
| MYO9A | Myosin IXA | Myosins are actin-based motor molecules with ATPase activity Unconventional myosins serve in intracellular movements |
|
| NCAPG | Non-SMC condensin I complex, subunit G | CAPG, CHCG, NY-MEL-3, YCG1 | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes |
| ND2 | NADH dehydrogenase subunit 2 | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) | |
| NFYB | Nuclear transcription factor Y β | CBF-A, CBF-B, HAP3, NF-YB | Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters |
| NKX3-2 | NK3 homeobox 2 | BAPX1, NKX3.2, NKX3B, SMMD | Transcriptional repressor that acts as a negative regulator of chondrocyte maturation |
| NLK | Nemo-like kinase | Role in cell fate determination, required for differentiation of bone marrow stromal cells | |
| NMRK2 | Nicotinamide riboside kinase 2 | ITGB1BP3, MIBP, NRK2 | |
| NOL4 | Nucleolar protein 4 | HRIHFB2255, CT125, NOLP | |
| NOTCH1 | Notch 1 | TAN1, hN1 | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell fate determination |
| NOTCH2 | Notch 2 | AGS2, HJCYS, hN2 | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell fate determination |
| NR6A1 | Nuclear receptor subfamily 6, group A, member 1 | CT150, GCNF, GCNF1, NR61, RTR, hGCNF, hRTR | Orphan nuclear receptor. May be involved in the regulation of gene expression in germ cell development during gametogenesis |
| NRP1 | Neuropilin 1 | RP11-342D11.1, BDCA4, CD304, NP1, NRP, VEGF165R | The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits, and in organogenesis outside the nervous system |
| NUDT12 | Nudix-type motif 12 | Hydrolyzes NAD(P)H to NMNH and AMP (2′,5′-ADP), and diadenosine diphosphate to AMP | |
| NUPL1 | Nucleoporin like 1 | RP11-206I15.1, PRO2463 | Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane |
| OAZ1 | Ornithine decarboxylase antizyme 1 | AZI, OAZ | Binds to and destabilizes ornithine decarboxylase, which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter |
| OCA2 | Oculocutaneous albinism II | BEY, BEY1, BEY2, BOCA, D15S12, EYCL, EYCL2, EYCL3, HCL3, P, PED, SHEP1 | Could be involved in the transport of tyrosine |
| OFCC1 | Orofacial cleft 1 candidate 1 | MRDS1 | |
| OR11A1 | Olfactory receptor, family 11, subfamily A, member 1 | DAAP-34I1.2, 6M1-18, OR11A2, dJ994E9.6, hs6M1-18 | Odorant receptor |
| OTUD1 | OTU deubiquitinase 1 | DUBA7, OTDC1 | Deubiquitinating enzyme that specifically hydrolyzes “Lys-63”- linked polyubiquitin to monoubiquitin |
| OTX2 | Orthodenticle homeobox 2 | CPHD6, MCOPS5 | Probably plays a role in the development of the brain and the sense organs |
| PABPC1 | Poly(A) binding protein, cytoplasmic 1 | PAB1, PABP, PABP1, PABPC2, PABPL1 | Binds the poly(A) tail of mRNA |
| PCAF | K(lysine) acetyltransferase 2B | CAF, P/CAF, PCAF | Functions as a component of the PCAF complex |
| PCDHB8 | Protocadherin β 8 | PCDH-β8, PCDH3I | Potential calcium-dependent cell-adhesion protein |
| PFKFB2 | 6-Phosphofructo-2-kinase/fructose-2, 6-biphosphatase 2 | RP11-164O23.2, PFK-2/FBPase-2 | Synthesis and degradation of fructose 2,6-bisphosphate |
| PGD | Phosphogluconate dehydrogenase | 6PGD | Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH |
| PHOX2A | Paired-like homeobox 2a | ARIX, CFEOM2, FEOM2, NCAM2, PMX2A | May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes |
| PHPT1 | Phosphohistidine phosphatase 1 | RP11-216L13.10-005, CGI-202, HEL-S-132P, HSPC141, PHP14 | Exhibits phosphohistidine phosphatase activity |
| PIM3 | Pim-3 proto-oncogene, serine/threonine kinase | CITF22-49E9.1, pim-3 | May be involved in cell cycle progression and antiapoptotic process |
| PITPNB | Phosphatidylinositol transfer protein β | RP3-353E16.2, PI-TP-β, PtdInsTP, VIB1B | Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes |
| PLA2G4C | Phospholipase A2, group IVC | CPLA2-γ | Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid |
| PLAG1 | Pleiomorphic adenoma gene 1 | PSA, SGPA, ZNF912 | Transcription factor whose activation results in upregulation of target genes, such as IGFII, leading to uncontrolled cell proliferation |
| PLCL2 | Phospholipase C-like 2 | PLCE2 | May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum |
| PLXDC2 | Plexin domain containing 2 | UNQ2514/PRO6003, TEM7R | May play a role in tumor angiogenesis |
| PNPT1 | Polyribonucleotide nucleotidyltransferase 1 | COXPD13, DFNB70, OLD35, PNPASE, old-35 | Involved in mRNA degradation |
| POLR2B | Polymerase (RNA) II (DNA directed) polypeptide B | POL2RB, RPB2, hRPB140, hsRPB2 | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA, using the four ribonucleoside triphosphates as substrates |
| PPA1 | Pyrophosphatase (inorganic) 1 | RP11-367H5.1, HEL-S-66p, IOPPP, PP, PP1, SID6-8061 | |
| PPM1A | Protein phosphatase, Mg2+/Mn2+ dependent, 1A | PP2C-ALPHA, PP2CA, PP2Cα | Enzyme with a broad specificity |
| PPP1R9A | Protein phosphatase 1, regulatory subunit 9A | NRB1, NRBI, Neurabin-I | Binds to actin filaments (F-actin) and shows crosslinking activity |
| PPP2CA | Protein phosphatase 2, catalytic subunit, α isozyme | PP2Ac, PP2CA, PP2Cα, RP-C | PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase |
| PPP2R5C | Protein phosphatase 2, regulatory subunit B’, γ | B56G, PR61G | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment |
| PRAP1 | Proline-rich acidic protein 1 | RP11-122K13.6, PRO1195, UPA | May play an important role in maintaining normal growth homeostasis in epithelial cells |
| PRDX3 | Peroxiredoxin 3 | AOP-1, AOP1, HBC189, MER5, PRO1748, SP-22, prx-III | Involved in redox regulation of the cell |
| PRLR | Prolactin receptor | HPRL, MFAB, hPRLrI | This is a receptor for the anterior pituitary hormone prolactin |
| PROSC | Proline synthetase co-transcribed homolog | ||
| PROX1 | Prospero homeobox 1 | May play a fundamental role in early development of the central nervous system | |
| PRR4 | Proline rich 4 | LPRP, PROL4 | |
| PRRC2B | Proline-rich coiled-coil 2B | RP11-334J6.1, BAT2L, BAT2L1, KIAA0515, LQFBS-1 | |
| PTGS2 | Prostaglandin-endoperoxide synthase 2 | COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity |
| PTPLAD1 | Protein tyrosine phosphatase-like A domain containing 1 | B-IND1, HACD3, HSPC121 | Involved in Rac1-signaling pathways leading to the modulation of gene expression |
| PTPN11 | Protein tyrosine phosphatase, non-receptor type 11 | BPTP3, CFC, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2 | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus |
| PTPN22 | Protein tyrosine phosphatase, non-receptor type 22 | LYP, LYP1, LYP2, PEP, PTPN8 | Seems to act on casitas B-lineage lymphoma (Cbl) |
| PTPRZ1 | Protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | HPTPZ, HPTPζ, PTP-ζ, PTP18, PTPRZ, PTPZ, R-PTP-ζ-2, RPTPB, RPTPβ, phosphacan | May be involved in the regulation of specific developmental processes in the central nervous system |
| PUM1 | Pumilio RNA-binding family member 1 | RP1-65J11.4, HSPUM, PUMH, PUMH1, PUML1 | Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3′-UTR of mRNA targets |
| RAB8B | RAB8B, member RAS oncogene family | May be involved in vesicular trafficking and neurotransmitter release | |
| RALA | V-ral simian leukemia viral oncogene homolog A | RAL | Multifunctional GTPase involved in a variety of cellular processes, including gene expression, cell migration, cell proliferation, oncogenic transformation, and membrane trafficking |
| RASSF6 | Ras association (RalGDS/AF-6) domain family member 6 | May act as a Ras effector protein | |
| RBM15 | RNA binding motif protein 15 | OTT, OTT1, SPEN | May be implicated in HOX gene regulation |
| RLF | Rearranged L-myc fusion | RP1-39G22.1, ZN-15L, ZNF292L | May be involved in transcriptional regulation |
| RNF2 | Ring finger protein 2 | GS1-120K12.1, BAP-1, BAP1, DING, HIPI3, RING1B, RING2 | E3 ubiquitin-protein ligase that mediates monoubiquitination of “Lys-119” of histone H2A, playing a central role in histone code and gene regulation |
| RNF34 | Ring finger protein 34 | CARP-1, CARP1, RFI, RIF, RIFF, hRFI | Has E3 ubiquitin-protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation |
| ROPN1L | Rhophilin associated tail protein 1-like | RP11-1C1.7, ASP, RSPH11 | |
| RPL14 | Ribosomal protein L14 | CAG-ISL-7, CTG-B33, L14, RL14, hRL14 | |
| RPS14 | Ribosomal protein S14 | PRO2640, EMTB, S14 | |
| RPS8 | Ribosomal protein S8 | RP11-269F19.3, S8 | |
| RTEL1-TNFRSF6B | RTEL1-TNFRSF6B readthrough (NMD candidate) | ||
| S100A1 | S100 calcium binding protein A1 | RP1-178F15.1, S100, S100-α, S100A | Weakly binds calcium but binds zinc very tightly – distinct binding sites with different affinities exist for both ions on each monomer |
| SCAMP2 | Secretory carrier membrane protein 2 | Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface | |
| SCD | Stearoyl-CoA desaturase | PRO1933, FADS5, MSTP0081, SCDOS, SCD | Terminal component of the liver microsomal stearyl-CoA desaturase system |
| SEPT2 | Septin 2 | DIFF6, NEDD-5, NEDD5, Pnutl3, hNedd5 | Required for normal progress through mitosis. Involved in cytokinesis |
| SF3B3 | Splicing factor 3b, subunit 3 | RSE1, SAP130, SF3b130, STAF13 | Subunit of the splicing factor SF3B required for “A” complex assembly formed by the stable binding of U2 snRNP to the branch point sequence in pre-mRNA |
| SH3BGRL | SH3 domain binding glutamate-rich protein like | HEL-S-115, SH3BGR | |
| SIK2 | Salt-inducible kinase 2 | LOH11CR1I, QIK, SNF1LK2 | Phosphorylates “Ser-794” of IRS1 in insulin-stimulated adipocytes |
| SIRT1 | Sirtuin 1 | RP11-57G10.3, SIR2L1 | NAD-dependent deacetylase, which regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins |
| SIX6 | SIX homeobox 6 | MCOPCT2, OPTX2, Six9 | May be involved in eye development |
| SLC35B4 | Solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 | PSEC0055, YEA, YEA4 | Sugar transporter that specifically mediates the transport of UDP-Xyl and UDP-GlcNAc from cytosol into Golgi |
| SLC37A3 | Solute carrier family 37, member 3 | ||
| SLC7A11 | Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | CCBR1, xCT | Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate |
| SLCO2A1 | Solute carrier organic anion transporter family, member 2A1 | MATR1, OATP2A1, PGT, PHOAR2, SLC21A2 | May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation |
| SMAD5 | SMAD family member 5 | DWFC, JV5-1, MADH5 | Transcriptional modulator activated by BMP type 1 receptor kinase |
| SMCHD1 | Structural maintenance of chromosomes flexible hinge domain containing 1 | Required for maintenance of X inactivation in females and hypermethylation of CpG islands associated with inactive X | |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 61E3.4, ATX, LIP | Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways |
| SNAI2 | Snail family zinc finger 2 | SLUG, SLUGH1, SNAIL2, WS2D | Transcriptional repressor. Involved in the generation and migration of neural crest cells |
| SOGA2 | Microtubule crosslinking factor 1 | CCDC165, KIAA0802, MTCL1 | |
| SPRY2 | Sprouty homolog 2 | hSPRY2 | May function as an antagonist of FGF pathways and may negatively modulate respiratory organogenesis |
| SRPK2 | SRSF protein kinase 2 | SFRSK2 | Phosphorylates RS domain-containing proteins |
| SRSF7 | Serine/arginine-rich splicing factor 7 | 9G8, AAG3, SFRS7 | Required for pre-mRNA splicing |
| STAG2 | Stromal antigen 2 | RP11-517O1.1, SA-2, SA2, SCC3B, bA517O1.1 | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication |
| TAAR6 | Trace amine associated receptor 6 | RP11-295F4.3, TA4, TAR4, TAR6, TRAR4, taR-4, taR-6 | Orphan receptor. Could be a receptor for trace amines |
| TAB2 | TGF-β activated kinase 1/MAP3K7 binding protein 2 | CHTD2, MAP3K7IP2, TAB-2 | Adapter linking MAP3K7/TAK1 and TRAF6 and mediator of MAP3K7 activation in the IL1 signaling pathway |
| TAF15 | TAF15 RNA polymerase II, TBP-associated factor | Npl3, RBP56, TAF2N, TAFII68 | RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters |
| TAF2 | TAF2 RNA polymerase II, TBP-associated factor | CIF150, MRT40B, TAFII150, TAF2 | Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II |
| TAF6L | TAF6-like RNA polymerase II, PCAF-associated factor | PAF65A | Functions as a component of the PCAF complex |
| TBX4 | T-box 4 | SPS | Involved in the transcriptional regulation of genes required for mesoderm differentiation |
| TCF21 | Transcription factor 21 | POD1, bHLHa23 | Involved in epithelial–mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis |
| TEAD4 | TEA domain family member 4 | EFTR-2, RTEF1, TCF13L1, TEF-3, TEF3, TEFR-1, hRTEF-1B | Binds specifically and noncooperatively to the Sph and GT-IIC “enhansons” (5′-GTGGAATGT-3′) and activates transcription |
| TGFBR3 | Transforming growth factor β receptor III | BGCAN, β-glycan | Binds to TGF-β |
| TGIF2 | TGFβ-induced factor homeobox 2 | Transcriptional repressor. Probably represses transcription via the recruitment of histone deacetylase proteins | |
| THUMPD1 | THUMP domain containing 1 | ||
| TIAL1 | TIA1 cytotoxic granule-associated RNA binding protein-like 1 | TCBP, TIAR | RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis |
| TM9SF3 | Transmembrane 9 superfamily member 3 | RP11-34E5.1, EP70-P-iso, SMBP | |
| TMED4 | Transmembrane emp24 protein transport domain containing 4 | ERS25, HNLF | Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis |
| TMEM132B | Transmembrane protein 132B | ||
| TMEM14A | Transmembrane protein 14A | PTD011, C6orf73 | |
| TMEM192 | Transmembrane protein 192 | ||
| TMEM257 | Transmembrane protein 257 | CXorf1 | |
| TMEM45A | Transmembrane protein 45A | DERP7 | |
| TMEM64 | Transmembrane protein 64 | ||
| TMPO | Thymopoietin | CMD1T, LAP2, LEMD4, PRO0868, TP | May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope |
| TMPRSS11A | Transmembrane protease, serine 11A | ECRG1 | Probable serine protease, which may play a role in cellular senescence |
| TNIP1 | TNFAIP3 interacting protein 1 | ABIN-1, NAF1, VAN, nip40-1 | Interacts with zinc finger protein A20/TNFAIP3 and inhibits TNF-induced NF-κB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal |
| TNPO1 | Transportin 1 | IPO2, KPNB2, MIP, MIP1, TRN | Functions in nuclear protein import as nuclear transport receptor |
| TNRC6C | Trinucleotide repeat containing 6C | Plays a role in RNA-mediated gene silencing by miRNAs | |
| TRIM2 | Tripartite motif containing 2 | CMT2R, RNF86 | May contribute to the alteration of neural cellular mechanisms |
| TRUB1 | TruB psi synthase family member 1 | PUS4 | May be responsible for synthesis of psi from uracil in transfer RNAs |
| TSG101 | Tumor susceptibility 101 | TSG10, VPS23 | Component of the ESCRT-I complex, a regulator of vesicular trafficking process |
| TSHR | Thyroid stimulating hormone receptor | CHNG1, LGR3, hTSHR-I | Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism |
| TUSC1 | Tumor suppressor candidate 1 | TSG-9, TSG9 | |
| TWF1 | Twinfilin actin-binding protein 1 | A6, PTK9 | Actin-binding protein involved in motile and morphological processes |
| UBA2 | Ubiquitin-like modifier activating enzyme 2 | HRIHFB2115, ARX, SAE2 | The dimeric enzyme acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4 |
| UCHL1 | Ubiquitin carboxyl-terminal esterase L1 | HEL-117, NDGOA, PARK5, PGP 9.5, PGP9.5, PGP95, Uch-L1 | Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins |
| UGT3A1 | UDP glycosyltransferase 3 family, polypeptide A1 | UDP-glucuronosyltransferases catalyze phase II biotransformation reactions | |
| USP28 | Ubiquitin specific peptidase 28 | Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability | |
| VBP1 | Von Hippel-Lindau binding protein 1 | RP13-228J13.4, PFD3, PFDN3, VBP-1 | Binds specifically to c-CPN and transfers target proteins to it |
| WDR33 | WD repeat domain 33 | NET14, WDC146 | Essential for both cleavage and polyadenylation of pre-mRNA 3′ ends |
| WNT16 | Wingless-type MMTV integration site family, member 16 | Ligand for members of the Frizzled family of seven transmembrane receptors | |
| WNT2 | Wingless-type MMTV integration site family, member 2 | INT1L1, IRP | Ligand for members of the Frizzled family of seven transmembrane receptors |
| WNT3A | Wingless-type MMTV integration site family member 3A | Ligand for members of the Frizzled family of seven transmembrane receptors | |
| XIAP | X-linked inhibitor of apoptosis | RP1-315G1.5, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 | Apoptotic suppressor |
| YOD1 | YOD1 deubiquitinase | RP11-164O23.1, DUBA8, OTUD2, PRO0907 | May play an important regulatory role at the level of protein turnover by preventing degradation |
| YY1 | YY1 transcription factor | DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1 | May play an important role in development and differentiation |
| ZEB2 | Zinc finger E-box binding homeobox 2 | HRIHFB2411, HSPC082, SIP-1, SIP1, SMADIP1, ZFHX1B | Transcriptional inhibitor that binds to DNA sequence 5′-CACCT-3′ in different promoters. Represses transcription of E-cadherin |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | BRF2, ERF-2, ERF2, RNF162C, TIS11D | Probable regulatory protein involved in regulating the response to growth factors |
| ZIC2 | Zinc family member 2 | HPE5 | Involved in cerebellar development |
| ZNF12 | Zinc finger protein 12 | GIOT-3, HZF11, KOX3, ZNF325 | May be involved in transcriptional regulation |
| ZNF121 | Zinc finger protein 121 | D19S204, ZHC32, ZNF20 | May be involved in transcriptional regulation |
| ZNF132 | Zinc finger protein 132 | pHZ-12 | May be involved in transcriptional regulation |
| ZNF148 | Zinc finger protein 148 | BERF-1, BFCOL1, HT-β, ZBP-89, ZFP148, pHZ-52 | Involved in transcriptional regulation |
| ZNF180 | Zinc finger protein 180 | HHZ168 | May be involved in transcriptional regulation |
| ZNF238 | Zinc finger and BTB domain containing 18 | C2H2-171, MRD22, RP58, TAZ-1, ZNF18 | Sequence-specific DNA-binding protein with transcriptional repression activity |
| ZNF25 | Zinc finger protein 25 | KOX19, Zfp9 | May be involved in transcriptional regulation |
| ZNF30 | Zinc finger protein 30 | KOX28 | May be involved in transcriptional regulation |
| ZNF35 | Zinc finger protein 35 | HF.10, HF10, Zfp105 | May be involved in transcriptional regulation |
| ZNF350 | Zinc finger protein 350 | ZBRK1, ZFQR | Transcriptional repressor |
| ZNF426 | Zinc finger protein 426 | May be involved in transcriptional regulation | |
| ZNF445 | Zinc finger protein 445 | ZKSCAN15, ZNF168, ZSCAN47 | May be involved in transcriptional regulation |
| ZNF558 | Zinc finger protein 558 | May be involved in transcriptional regulation | |
| ZNF562 | Zinc finger protein 562 | May be involved in transcriptional regulation | |
| ZNF594 | Zinc finger protein 594 | hCG_1775942 | May be involved in transcriptional regulation |
| ZNF644 | Zinc finger protein 644 | BM-005, MYP21, NatF, ZEP-2 | May be involved in transcriptional regulation |
| ZNF652 | Zinc finger protein 652 | Functions as a transcriptional repressor | |
| ZNF700 | Zinc finger protein 700 | May be involved in transcriptional regulation | |
| ZNF703 | Zinc finger protein 703 | ZEPPO1, ZNF503L, ZPO1 | May function as a transcriptional repressor |
| ZNF711 | Zinc finger protein 711 | CMPX1, MRX97, ZNF4, ZNF5, ZNF6, Zfp711, dJ75N13.1 | May be involved in transcriptional regulation |
| ZNF763 | Zinc finger protein 763 | ZNF, ZNF440L | May be involved in transcriptional regulation |
| ZNF780A | Zinc finger protein 780A | ZNF780 | May be involved in transcriptional regulation |
Abbreviations: FGF, fibroblast growth factor; HLA, human leukocyte antigen; IL, interleukin; miRNA, microRNA; mRNA, messenger RNA; NK cells, natural killer cells; ssDNA, single-stranded DNA; TGF, Transforming growth factor; TNF, tumor necrosis factor; UV, ultraviolet; VEGF, vascular endothelial growth factor.