TABLE 1.

Antibacterial effect of pharmacokinetically enhanced amoxicillin-clavulanate (2,000 mg of amoxicillin) on S. pneumoniae

Strain	Amoxicillin-clavulanate MICa (mg/liter)	Inoculum (log CFU/ml)	Log CFU/ml (mean ± SD)				T99(h)	T99.9(h)	AUBKC (log CFU/ml · h)
			Δ3	Δ6	Δ12	Δ24			0-12 h	0-24 h
05010S	3	6	−2.9 ± 0.3	−4.0 ± 0.1	−4.0 ± 0.1	−4.0 ± 0.1	2	2	8.9 ± 3.0	8.9 ± 3.0
		8	−1.4 ± 0.2	−3.3 ± 0.1	−5.5 ± 0.8	−6.5 ± 0.1	5	6	37.1 ± 2.0	48.1 ± 4.3
016001S	4	6	−2.0 ± 0.3	−3.3 ± 0.4	−4.1 ± 0.2	−4.1 ± 0.2	4	6	16.0 ± 1.7	16.0 ± 1.7
		8	−0.7 ± 0.2	−2.0 ± 0.4	−3.7 ± 0.2	−6.2 ± 0.1	6	12	49.4 ± 2.4	62.0 ± 4.0
30005S	5	6	−2.3 ± 0.1	−3.5 ± 0.1	−4.0 ± 0.4	−4.1	3	6	14.1 ± 1.8	15.6 ± 1.5
		8	−1.8 ± 0.2	−3.7 ± 0.3	−5.2 ± 0.2	−6.1 ± 0.1	4	6	34.3 ± 1.8	38.8 ± 2.5
47003S	6	6	−3.4 ± 0.3	−3.9 ± 0.1	−2.8 ± 0.8	−4.1 ± 0.1	1	2	9.2 ± 4.1	15.3 ± 8.0
		8	−0.9 ± 0.2	−2.5 ± 0.1	−4.4 ± 0.2	−5.4 ± 1.0	5	12	45.5 ± 0.8	59.6 ± 9.6
05003S	8	6	−1.6 ± 0.2	−3.2 ± 0.1	−4.0 ± 0.3	−3.1 ± 0.8	4	6	15.8 ± 1.8	20.3 ± 2.6
		8	−0.8 ± 0.1	−2.4 ± 0.2	−4.7 ± 0.1	−6.2 ± 0.1	6	12	45.1 ± 1.8	52.3 ± 2.9
404053	8	6	−1.7 ± 0.1	−2.7 ± 0.2	−3.7 ± 0.3	−4.0 ± 0.4	4	12	18.7 ± 1.3	21.7 ± 3.6
		8	−0.6 ± 0.2	−1.9 ± 0.2	−3.2 ± 0.2	0 ± 0.2	6	12	50.8 ± 1.5	103.6 ± 3.2

^aDetermined using BSAC methodology.